4-(2-ethoxy-6-pentadecylbenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide

Base Information

• Chemical Name: 4-(2-ethoxy-6-pentadecylbenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide
• CAS No.: 485386-85-4
• Molecular Formula: C₃₂H₅₂N₄O₃
• Molecular Weight: 540.79
• Mol file: 485386-85-4.mol

Synonyms:4-(2-ethoxy-6-pentadecylbenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide

Chemical Property of 4-(2-ethoxy-6-pentadecylbenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-ethoxy-6-pentadecylbenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide

There total 3 articles about 4-(2-ethoxy-6-pentadecylbenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide (139756-02-8) + 2-ethoxy-6-pentadecylbenzoic acid chloride (485386-83-2) → 4-(2-ethoxy-6-pentadecylbenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide (485386-85-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 5 ℃; for 1h;

DOI:10.1021/jf0258050

Reference yield:

6-Pentadecylsalicylic Acid (16611-84-0) → 4-(2-ethoxy-6-pentadecylbenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide (485386-85-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / K₂CO₃ / acetone / 3 h / Heating

2: 80 percent / tBuOK / dimethylsulfoxide / 2 h / 70 °C

3: SOCl₂; DMF / hexane / 1 h / Heating

4: 72 percent / Et₃N / CH₂Cl₂ / 1 h / 0 - 5 °C

With thionyl chloride; potassium tert-butylate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In hexane; dichloromethane; dimethyl sulfoxide; acetone;

DOI:10.1021/jf0258050

Reference yield:

ethyl 2-methoxy-6-pentadecylbenzoate (485386-80-9) → 4-(2-ethoxy-6-pentadecylbenzamido)-1-methyl-3-n-propylpyrazole-5-carboxamide (485386-85-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / tBuOK / dimethylsulfoxide / 2 h / 70 °C

2: SOCl₂; DMF / hexane / 1 h / Heating

3: 72 percent / Et₃N / CH₂Cl₂ / 1 h / 0 - 5 °C

With thionyl chloride; potassium tert-butylate; triethylamine; N,N-dimethyl-formamide; In hexane; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jf0258050

upstream raw materials:

4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

2-ethoxy-6-pentadecylbenzoic acid chloride

6-Pentadecylsalicylic Acid

ethyl 2-methoxy-6-pentadecylbenzoate

Downstream raw materials:

4-[2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide

4-[2-ethoxy-5-(chlorosulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide