ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-2-(chloromethyl)-5-cyanonicotinate

Base Information

Chemical Name:ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-2-(chloromethyl)-5-cyanonicotinate
CAS No.:1001025-97-3
Molecular Formula:C₂₃H₂₅ClN₄O₅S
Molecular Weight:504.994
Hs Code.:

Synonyms:ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-2-(chloromethyl)-5-cyanonicotinate

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Chemical Property of ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-2-(chloromethyl)-5-cyanonicotinate

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Technology Process of ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-2-(chloromethyl)-5-cyanonicotinate

There total 4 articles about ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-2-(chloromethyl)-5-cyanonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 919354-21-5
N-(benzylsulfonyl)piperidine-4-carboxamide

: 1001026-23-8
ethyl 6-chloro-2-(chloromethyl)-5-cyanonicotinate

: 1001025-97-3
ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-2-(chloromethyl)-5-cyanonicotinate

Guidance literature:: With triethylamine; at 100 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 4563-33-1
phenyl-methanesulfonic acid amide

: 1001025-97-3
ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-2-(chloromethyl)-5-cyanonicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 0.67 h / 20 °C

1.2: 20 °C

2.1: formic acid / 18 h / 20 °C

2.2: 2 h / 20 °C / pH 6

3.1: triethylamine / ethanol / 18 h / 72 °C

With formic acid; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/acs.jmedchem.8b01971

Reference yield:

: 638-07-3
ethyl (2-chloroaceto)acetate

: 1001025-97-3
ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-2-(chloromethyl)-5-cyanonicotinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic anhydride / 3 h / 120 °C

1.2: 16 h / Inert atmosphere; Reflux

2.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 16 h / Inert atmosphere; Reflux

3.1: triethylamine / ethanol / 18 h / 72 °C

With thionyl chloride; acetic anhydride; triethylamine; N,N-dimethyl-formamide; In ethanol; dichloromethane; 1.2: |Hantzsch Dihydropyridine Synthesis;
DOI:10.1021/acs.jmedchem.8b01971