methyl 3-[[1-[5-[(2-naphthalenylcarbonyl)amino]-2-pyridinyl]-4-piperidinyl]methoxy]benzoate

Base Information

Chemical Name:methyl 3-[[1-[5-[(2-naphthalenylcarbonyl)amino]-2-pyridinyl]-4-piperidinyl]methoxy]benzoate
CAS No.:1360801-32-6
Molecular Formula:C₃₀H₂₉N₃O₄
Molecular Weight:495.578
Hs Code.:

Synonyms:methyl 3-[[1-[5-[(2-naphthalenylcarbonyl)amino]-2-pyridinyl]-4-piperidinyl]methoxy]benzoate

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Chemical Property of methyl 3-[[1-[5-[(2-naphthalenylcarbonyl)amino]-2-pyridinyl]-4-piperidinyl]methoxy]benzoate

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Technology Process of methyl 3-[[1-[5-[(2-naphthalenylcarbonyl)amino]-2-pyridinyl]-4-piperidinyl]methoxy]benzoate

There total 6 articles about methyl 3-[[1-[5-[(2-naphthalenylcarbonyl)amino]-2-pyridinyl]-4-piperidinyl]methoxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227935-30-9
methyl 3-((1-(5-aminopyridin-2-yl)piperidin-4-yl)methoxy)benzoate

: 93-09-4
naphthalene-2-carboxylate

: 1360801-32-6
methyl 3-[[1-[5-[(2-naphthalenylcarbonyl)amino]-2-pyridinyl]-4-piperidinyl]methoxy]benzoate

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1227935-27-4
(1-(5-nitropyridin-2-yl)piperidin-4-yl)methanol

: 1360801-32-6
methyl 3-[[1-[5-[(2-naphthalenylcarbonyl)amino]-2-pyridinyl]-4-piperidinyl]methoxy]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1.25 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 5 h / 50 °C

3.1: hydrogen / platinum(IV) oxide / ethyl acetate; isopropyl alcohol / 16 h / 20 °C / Inert atmosphere

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogen; sodium hydride; triethylamine; HATU; platinum(IV) oxide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 1227935-28-5
(1-(5-nitropyridin-2-yl)piperidin-4-yl)methyl methanesulfonate

: 1360801-32-6
methyl 3-[[1-[5-[(2-naphthalenylcarbonyl)amino]-2-pyridinyl]-4-piperidinyl]methoxy]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

1.2: 5 h / 50 °C

2.1: hydrogen / platinum(IV) oxide / ethyl acetate; isopropyl alcohol / 16 h / 20 °C / Inert atmosphere

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogen; sodium hydride; triethylamine; HATU; platinum(IV) oxide; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;