(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholin-4-yl)ethyl>oxazolidin-2-one

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Chemical Name:(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholin-4-yl)ethyl>oxazolidin-2-one
CAS No.:131451-96-2
Molecular Formula:C₂₃H₃₄N₂O₄
Molecular Weight:402.534
Hs Code.:

Synonyms:(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholin-4-yl)ethyl>oxazolidin-2-one

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Chemical Property of (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholin-4-yl)ethyl>oxazolidin-2-one

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Technology Process of (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholin-4-yl)ethyl>oxazolidin-2-one

There total 10 articles about (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholin-4-yl)ethyl>oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 110-91-8,99108-56-2
morpholine

: 131451-95-1
(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-oxiran-2-yl>oxazolidin-2-one

: 131451-96-2
(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholin-4-yl)ethyl>oxazolidin-2-one

Guidance literature:: In methanol; for 24h; Ambient temperature;
DOI:10.1246/cl.1990.1709 DOI:10.1248/cpb.39.2550

Reference yield:

: 139056-96-5,139164-19-5
(4R,5R)-4-<(S)-(1-(N-Benzyl-N-methoxycarbonyl)amino-2-cyclohexyl)ethyl>-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane

: 131451-96-2
(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholin-4-yl)ethyl>oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 80percent AcOH / 5 h / 80 °C

2: KOH / methanol / 3.5 h / Ambient temperature

3: 96 percent / pyridine / 3 h / 0 °C

4: 98 percent / H₂ / 20percent Pd(OH)2/C / methanol / 48 h / 760 Torr / Ambient temperature

5: 94 percent / NaOMe / tetrahydrofuran / 0.5 h / 0 °C

6: 94 percent / methanol / 24 h / Ambient temperature

With pyridine; potassium hydroxide; hydrogen; sodium methylate; acetic acid; palladium dihydroxide; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.39.2550

Reference yield:

: 130914-06-6
(4R,5R)-4-<(S)-(1-N-Benzylamino-2-cyclohexyl)ethyl>-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane

: 131451-96-2
(4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholin-4-yl)ethyl>oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / K₂CO₃ / tetrahydrofuran / 7 h / 0 °C

2: 80percent AcOH / 5 h / 80 °C

3: KOH / methanol / 3.5 h / Ambient temperature

4: 96 percent / pyridine / 3 h / 0 °C

5: 98 percent / H₂ / 20percent Pd(OH)2/C / methanol / 48 h / 760 Torr / Ambient temperature

6: 94 percent / NaOMe / tetrahydrofuran / 0.5 h / 0 °C

7: 94 percent / methanol / 24 h / Ambient temperature

With pyridine; potassium hydroxide; hydrogen; sodium methylate; potassium carbonate; acetic acid; palladium dihydroxide; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.39.2550