(R)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]-triazole

Base Information

Chemical Name:(R)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]-triazole
CAS No.:1285819-64-8
Molecular Formula:C₁₅H₁₁ClN₆
Molecular Weight:310.746
Hs Code.:

Synonyms:(R)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]-triazole

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Chemical Property of (R)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]-triazole

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Technology Process of (R)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]-triazole

There total 7 articles about (R)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 247153-23-7
6-{(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl}-1H-benzo[d][1,2,3]triazole

: 1285819-64-8
(R)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]-triazole

: (S)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]triazole

Guidance literature:: With CHIRALPAK AD-H column; In methanol; ethanol; optical yield given as %ee; Resolution of racemate;
DOI:10.1016/j.bmc.2010.12.057

Reference yield:

: 1285819-57-9
4'-chloro-3,4-di(tert-butoxycarbonylamino)benzophenone

: 1285819-64-8
(R)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]-triazole

: (S)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]triazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 0 - 20 °C / Inert atmosphere

2.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

5.1: CHIRALPAK AD-H column / methanol; ethanol / Resolution of racemate

With hydrogenchloride; sodium tetrahydroborate; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; sodium nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2010.12.057

Reference yield:

: 1285819-58-0
4'-chloro-3,4-di(tert-butoxycarbonylamino)benzhydrol

: 1285819-64-8
(R)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]-triazole

: (S)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl)-1H-benzo[d][1,2,3]triazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

4.1: CHIRALPAK AD-H column / methanol; ethanol / Resolution of racemate

With hydrogenchloride; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; sodium nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2010.12.057