1-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

Base Information

• Chemical Name: 1-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide
• CAS No.: 1026646-41-2
• Molecular Formula: C₃₁H₃₃ClN₄O₅
• Molecular Weight: 577.08
• Mol file: 1026646-41-2.mol

Synonyms:1-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

Chemical Property of 1-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

There total 10 articles about 1-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-aza-9-hydroxy-9-fluorene carboxylic acid methyl ester (1026682-30-3) → 1-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide (1026646-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 96 percent / hydrazine / 2 h / 20 °C

2.1: HCl(gas); amyl nitrite / dimethylformamide; tetrahydrofuran / -20 °C / pH 1 - 2

2.2: 62 percent / N,N-diisopropylethylamine / dimethylformamide; tetrahydrofuran / 24 h / -20 °C

With hydrogenchloride; n-Amyl nitrite; hydrazine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm049423s

Reference yield:

9-trimethylsilanyloxy-9H-indeno[2,1-b]pyridine-9-carbonitrile → 1-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide (1026646-41-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 4.6 g / HCl(gas) / 4 h / 20 °C

2.1: 96 percent / hydrazine / 2 h / 20 °C

3.1: HCl(gas); amyl nitrite / dimethylformamide; tetrahydrofuran / -20 °C / pH 1 - 2

3.2: 62 percent / N,N-diisopropylethylamine / dimethylformamide; tetrahydrofuran / 24 h / -20 °C

With hydrogenchloride; n-Amyl nitrite; hydrazine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm049423s

Reference yield:

indeno[2,1-b]pyridin-9-one (57955-12-1) → 1-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide (1026646-41-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: zinc iodide / acetonitrile / 24 h / Heating

2.1: 4.6 g / HCl(gas) / 4 h / 20 °C

3.1: 96 percent / hydrazine / 2 h / 20 °C

4.1: HCl(gas); amyl nitrite / dimethylformamide; tetrahydrofuran / -20 °C / pH 1 - 2

4.2: 62 percent / N,N-diisopropylethylamine / dimethylformamide; tetrahydrofuran / 24 h / -20 °C

With hydrogenchloride; n-Amyl nitrite; zinc(II) iodide; hydrazine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm049423s

upstream raw materials:

1-aza-9-hydroxy-9-fluorene carboxylic acid methyl ester

indeno[2,1-b]pyridin-9-one

3-phenylpyridine-2-carboxylic acid

Fmoc-Pro-OH