2-(4'-carboxyphenyl)-9,9-bis(6'-tert-butoxycarbonylaminohexyl)fluorene

Base Information

• Chemical Name: 2-(4'-carboxyphenyl)-9,9-bis(6'-tert-butoxycarbonylaminohexyl)fluorene
• CAS No.: 853221-09-7
• Molecular Formula: C₄₂H₅₆N₂O₆
• Molecular Weight: 684.916
• Mol file: 853221-09-7.mol

Synonyms:2-(4'-carboxyphenyl)-9,9-bis(6'-tert-butoxycarbonylaminohexyl)fluorene

Chemical Property of 2-(4'-carboxyphenyl)-9,9-bis(6'-tert-butoxycarbonylaminohexyl)fluorene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(4'-carboxyphenyl)-9,9-bis(6'-tert-butoxycarbonylaminohexyl)fluorene

There total 4 articles about 2-(4'-carboxyphenyl)-9,9-bis(6'-tert-butoxycarbonylaminohexyl)fluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.8%

2-bromo-9,9-bis(6'-tert-butoxycarbonylaminohexyl)fluorene (853221-07-5) + 4-carboxyphenylboronic acid (14047-29-1) → 2-(4'-carboxyphenyl)-9,9-bis(6'-tert-butoxycarbonylaminohexyl)fluorene (853221-09-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; for 24h; Heating;

DOI:10.1021/ol047674p

Reference yield:

2-bromo-9,9-bis(6'-aminohexyl)fluorene (853221-05-3) → 2-(4'-carboxyphenyl)-9,9-bis(6'-tert-butoxycarbonylaminohexyl)fluorene (853221-09-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 64.5 percent / tetrahydrofuran / 2 h / 20 °C

2: 43.8 percent / Pd(PPh₃)4; Na₂CO₃ / tetrahydrofuran; H₂O / 24 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; 2: Suzuki coupling;

DOI:10.1021/ol047674p

Reference yield:

2-bromo-9,9-bis(6'-azidohexyl)fluorene (853221-04-2) → 2-(4'-carboxyphenyl)-9,9-bis(6'-tert-butoxycarbonylaminohexyl)fluorene (853221-09-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 76.4 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

2: 64.5 percent / tetrahydrofuran / 2 h / 20 °C

3: 43.8 percent / Pd(PPh₃)4; Na₂CO₃ / tetrahydrofuran; H₂O / 24 h / Heating

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; 3: Suzuki coupling;

DOI:10.1021/ol047674p

upstream raw materials:

2-bromo-9,9-bis(6'-tert-butoxycarbonylaminohexyl)fluorene

4-carboxyphenylboronic acid

2-bromo-9,9-bis(6'-aminohexyl)fluorene

2-bromo-9,9-bis(6'-azidohexyl)fluorene