benzyl 2-<(2R,R_S)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate

Base Information

• Chemical Name: benzyl 2-<(2R,R_S)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate
• CAS No.: 156855-93-5
• Molecular Formula: C₂₂H₂₄N₂O₄S
• Molecular Weight: 412.51
• Mol file: 156855-93-5.mol

Synonyms:benzyl 2-<(2R,R_S)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate

Chemical Property of benzyl 2-<(2R,R_S)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-<(2R,R_S)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate

There total 4 articles about benzyl 2-<(2R,R_S)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-((R)-2-Methoxysulfinyl-4-oxo-azetidin-1-yl)-3-methyl-but-2-enoic acid benzyl ester + benzylamine (100-46-9) → benzyl 2-<(2R,SS)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate (151648-26-9) + benzyl 2-<(2R,RS)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate (156855-93-5)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, 30 min, 2.) CH₂Cl₂, RT, 30 min;

DOI:10.1016/0957-4166(94)80131-2

Reference yield:

2-((R)-2-Chlorosulfinyl-4-oxo-azetidin-1-yl)-3-methyl-but-2-enoic acid benzyl ester + benzylamine (100-46-9) → benzyl 2-<(2R,SS)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate (151648-26-9) + benzyl 2-<(2R,RS)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate (156855-93-5)

Guidance literature:

In dichloromethane; for 0.5h; Ambient temperature;

Reference yield:

2-((R)-2-(S)-Chlorosulfinyl-4-oxo-azetidin-1-yl)-3-methyl-but-2-enoic acid benzyl ester (127444-44-4) + benzylamine (100-46-9) → benzyl 2-<(2R,SS)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate (151648-26-9) + benzyl 2-<(2R,RS)-2-benzylsulphinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate (156855-93-5)

Guidance literature:

In dichloromethane; for 0.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

upstream raw materials:

benzylamine

2-((R)-2-(S)-Chlorosulfinyl-4-oxo-azetidin-1-yl)-3-methyl-but-2-enoic acid benzyl ester

2-((R)-2-(R)-Chlorosulfinyl-4-oxo-azetidin-1-yl)-3-methyl-but-2-enoic acid benzyl ester

Downstream raw materials:

ethoxycarbonyl 2-<(2R,R_S)-2-benzylsulfinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoate

methyl (2R,R_S)-1-(1-benzylcarbamoyl-2-methylpropenyl)-4-oxoazetidine-2-sulfinate

(5R,6R)-4-benzyl-2-isopropylidene-5-oxo-5-thia-1,4-diazabicyclo<4.2.0>octane-3,8-dione

2-<(2R,R_S)-2-benzylsulfinamoyl-4-oxoazetidin-1-yl>-3-methylbut-2-enoic acid