ethyl 2-acetamido-2-ethoxycarbonyl-3-(3-ethoxy-4-phenyl-5-isoxazolyl)propionate

Base Information

Chemical Name:ethyl 2-acetamido-2-ethoxycarbonyl-3-(3-ethoxy-4-phenyl-5-isoxazolyl)propionate
CAS No.:334887-46-6
Molecular Formula:C₂₁H₂₆N₂O₇
Molecular Weight:418.447
Hs Code.:

Synonyms:ethyl 2-acetamido-2-ethoxycarbonyl-3-(3-ethoxy-4-phenyl-5-isoxazolyl)propionate

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Chemical Property of ethyl 2-acetamido-2-ethoxycarbonyl-3-(3-ethoxy-4-phenyl-5-isoxazolyl)propionate

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Technology Process of ethyl 2-acetamido-2-ethoxycarbonyl-3-(3-ethoxy-4-phenyl-5-isoxazolyl)propionate

There total 3 articles about ethyl 2-acetamido-2-ethoxycarbonyl-3-(3-ethoxy-4-phenyl-5-isoxazolyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 334887-45-5
5-bromomethyl-3-ethoxy-4-phenylisoxazole

: 334887-46-6
ethyl 2-acetamido-2-ethoxycarbonyl-3-(3-ethoxy-4-phenyl-5-isoxazolyl)propionate

Guidance literature:: 2-acetylaminomalonic acid diethyl ester; With sodium hydride; In N,N-dimethyl-formamide; for 0.25h;

5-bromomethyl-3-ethoxy-4-phenylisoxazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Further stages.;
DOI:10.1021/jm000441t

Reference yield:

: 27772-79-8
3-hydroxy-5-methyl-4-phenylisoxazole

: 334887-46-6
ethyl 2-acetamido-2-ethoxycarbonyl-3-(3-ethoxy-4-phenyl-5-isoxazolyl)propionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 0.5 h / 60 °C

1.2: 67 percent / acetone / 4 h / Heating

2.1: 72 percent / dibenzoyl peroxide; NBS / CCl₄ / 15 h / Heating

3.1: NaH / dimethylformamide / 0.25 h

3.2: 60 percent / dimethylformamide / 24 h / 20 °C

With N-Bromosuccinimide; sodium hydride; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm000441t

Reference yield:

: 146197-26-4
3-ethoxy-5-methyl-4-phenylisoxazole

: 334887-46-6
ethyl 2-acetamido-2-ethoxycarbonyl-3-(3-ethoxy-4-phenyl-5-isoxazolyl)propionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 72 percent / dibenzoyl peroxide; NBS / CCl₄ / 15 h / Heating

2.1: NaH / dimethylformamide / 0.25 h

2.2: 60 percent / dimethylformamide / 24 h / 20 °C

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000441t