5-[4-(2-{2-[2-(2-{1-[2-(2-{2-[2-(2-fluoropyridin-3-yloxy)ethoxy]ethoxy}ethoxy)ethyl]-1H-1,2,3-triazol-4-yl-methoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

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Chemical Name:5-[4-(2-{2-[2-(2-{1-[2-(2-{2-[2-(2-fluoropyridin-3-yloxy)ethoxy]ethoxy}ethoxy)ethyl]-1H-1,2,3-triazol-4-yl-methoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione
CAS No.:1351556-89-2
Molecular Formula:C₄₄H₅₇FN₈O₁₂
Molecular Weight:908.981
Hs Code.:

5-[4-(2-{2-[2-(2-{1-[2-(2-{2-[2-(2-fluoropyridin-3-yloxy)ethoxy]ethoxy}ethoxy)ethyl]-1H-1,2,3-triazol-4-yl-methoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

Synonyms:5-[4-(2-{2-[2-(2-{1-[2-(2-{2-[2-(2-fluoropyridin-3-yloxy)ethoxy]ethoxy}ethoxy)ethyl]-1H-1,2,3-triazol-4-yl-methoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

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Chemical Property of 5-[4-(2-{2-[2-(2-{1-[2-(2-{2-[2-(2-fluoropyridin-3-yloxy)ethoxy]ethoxy}ethoxy)ethyl]-1H-1,2,3-triazol-4-yl-methoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

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Technology Process of 5-[4-(2-{2-[2-(2-{1-[2-(2-{2-[2-(2-fluoropyridin-3-yloxy)ethoxy]ethoxy}ethoxy)ethyl]-1H-1,2,3-triazol-4-yl-methoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

There total 6 articles about 5-[4-(2-{2-[2-(2-{1-[2-(2-{2-[2-(2-fluoropyridin-3-yloxy)ethoxy]ethoxy}ethoxy)ethyl]-1H-1,2,3-triazol-4-yl-methoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1233816-90-4
5-[4-(3,6,9,12-tetraoxapentadec-14-ynyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

: 1268257-51-7
3-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)-2-fluoropyridine

: 1351556-89-2
5-[4-(2-{2-[2-(2-{1-[2-(2-{2-[2-(2-fluoropyridin-3-yloxy)ethoxy]ethoxy}ethoxy)ethyl]-1H-1,2,3-triazol-4-yl-methoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; at 20 ℃; for 2.5h;
DOI:10.1021/jm201142w

Reference yield:

: 1351556-84-7
3-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)-2-nitropyridine

: 1351556-89-2
5-[4-(2-{2-[2-(2-{1-[2-(2-{2-[2-(2-fluoropyridin-3-yloxy)ethoxy]ethoxy}ethoxy)ethyl]-1H-1,2,3-triazol-4-yl-methoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 90 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; N,N-dimethyl-formamide / 2.5 h / 20 °C

With copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm201142w

Reference yield:

: 5-bromo-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

: 1351556-89-2
5-[4-(2-{2-[2-(2-{1-[2-(2-{2-[2-(2-fluoropyridin-3-yloxy)ethoxy]ethoxy}ethoxy)ethyl]-1H-1,2,3-triazol-4-yl-methoxy}ethoxy)ethoxy]ethoxy}ethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 - 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; N,N-dimethyl-formamide / 2.5 h / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm201142w