N-2-(p-biphenylyl)isopropoxycarbonylasparaginyl-4-iodophenylalanyl-phenylalanine hydrazide

Base Information

• Chemical Name: N-2-(p-biphenylyl)isopropoxycarbonylasparaginyl-4-iodophenylalanyl-phenylalanine hydrazide
• CAS No.: 69994-35-0
• Molecular Formula: C₃₈H₄₁IN₆O₆
• Molecular Weight: 804.685

Synonyms:N-2-(p-biphenylyl)isopropoxycarbonylasparaginyl-4-iodophenylalanyl-phenylalanine hydrazide

Chemical Property of N-2-(p-biphenylyl)isopropoxycarbonylasparaginyl-4-iodophenylalanyl-phenylalanine hydrazide

Chemical Property:

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Technology Process of N-2-(p-biphenylyl)isopropoxycarbonylasparaginyl-4-iodophenylalanyl-phenylalanine hydrazide

There total 7 articles about N-2-(p-biphenylyl)isopropoxycarbonylasparaginyl-4-iodophenylalanyl-phenylalanine hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-2-(4-biphenylyl)isopropoxycarbonylasparaginyl-4-iodophenylalanyl-phenylalanine methyl ester (79385-57-2) → N-2-(p-biphenylyl)isopropoxycarbonylasparaginyl-4-iodophenylalanyl-phenylalanine hydrazide (69994-35-0)

Guidance literature:

With hydrazine hydrate; In N,N-dimethyl-formamide; for 18h;

DOI:10.1039/P19810002040

Reference yield:

N-Boc-4-I-Phe-OH (103882-09-3,62129-44-6) → N-2-(p-biphenylyl)isopropoxycarbonylasparaginyl-4-iodophenylalanyl-phenylalanine hydrazide (69994-35-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / triethylamine, dicyclohexylcarbodi-imide / dimethylformamide / 16 h / 4 °C

2: 1.7 M HCl / acetic acid; methanol / 3 h

3: dimethylformamide / 16 h / 4 °C

4: 86 percent / hydrazine hydrate / dimethylformamide / 18 h

With hydrogenchloride; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; In methanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1039/P19810002040

Reference yield:

Bpoc-Asn-OH (18635-06-8) → N-2-(p-biphenylyl)isopropoxycarbonylasparaginyl-4-iodophenylalanyl-phenylalanine hydrazide (69994-35-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexylcarbodi-imide / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 10 deg C, 1 h

2: dimethylformamide / 16 h / 4 °C

3: 86 percent / hydrazine hydrate / dimethylformamide / 18 h

With hydrazine hydrate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1039/P19810002040

upstream raw materials:

N-2-(4-biphenylyl)isopropoxycarbonylasparaginyl-4-iodophenylalanyl-phenylalanine methyl ester

Bpoc-Asn-OH

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

N-Boc-4-I-Phe-OH

Downstream raw materials:

Bpoc-Asn-Phe(I)-Phe-N₃

Bpoc-Asn-Phe(I)-Phe-Trp-Lys(Boc)-Thr(Bu^t)-OH

Bpoc-Asn-Phe(I)-Phe-D-Trp-Lys(Boc)-Thr(t-Bu)-OH

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