Giparmen

Base Information

Chemical Name:Giparmen
CAS No.:67268-43-3
Molecular Formula:C13H10O3
Molecular Weight:214.221
Hs Code.:
UNII:6272R7515Q
DSSTox Substance ID:DTXSID3045699
Nikkaji Number:J18.850F
Wikidata:Q27263450
NCI Thesaurus Code:C74115
ChEMBL ID:CHEMBL1377940

Synonyms:Giparmen;67268-43-3;Giparmen [INN];Giparmene;4-methyl-7-prop-2-ynoxychromen-2-one;4-Methyl-7-(2-propynyloxy)coumarin;Giparmenum;Giparmena;Giparmene [INN-French];Giparmenum [INN-Latin];Giparmena [INN-Spanish];4-methyl-7-(prop-2-yn-1-yloxy)-2H-chromen-2-one;4-Methyl-7-propargyloxy-cumarin [German];MLS000038971;DTXSID3045699;4-Methyl-7-propargyloxy-cumarin;UNII-6272R7515Q;4-Methyl-7-(2-propynyloxy)-2H-1-benzopyran-2-one;NCGC00063341-02;SMR000034335;6272R7515Q;2H-1-Benzopyran-2-one, 4-methyl-7-(2-propynyloxy)-;Opera_ID_1826;MLS001201787;MLS006011687;SCHEMBL2109323;CHEMBL1377940;DTXCID1025699;Tox21_110978;CCG-18561;STK874243;AKOS002238618;LS-39814;4-methyl-7-prop-2-ynyloxy-chromen-2-one;CAS-67268-43-3;CS-0366620;EU-0008602;AB00407147-11;SR-01000466278;SR-01000466278-1;Q27263450;4-Methyl-7-(2-propyn-1-yloxy)-2H-1-benzopyran-2-one;F0896-0457

Suppliers and Price of Giparmen

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Giparmen

Chemical Property:

Vapor Pressure:3.5E-06mmHg at 25°C
Boiling Point:386.6°C at 760 mmHg
Flash Point:162.8°C
PSA：39.44000
Density:1.218g/cm³
LogP:2.11340
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:214.062994177
Heavy Atom Count:16
Complexity:361

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=O)OC2=C1C=CC(=C2)OCC#C

Technology Process of Giparmen

There total 5 articles about Giparmen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 90-33-5,79566-13-5
7-hydroxy-4-methyl-chromen-2-one

: 106-96-7
propargyl bromide

: 67268-43-3
7-propargyloxy-4-methyl-2H-chromen-2-one

Guidance literature:: With potassium carbonate; In toluene; acetonitrile; at 60 ℃; Inert atmosphere;
DOI:10.1021/acs.inorgchem.5b01579

Reference yield: 40.2%

: 90-33-5,79566-13-5
7-hydroxy-4-methyl-chromen-2-one

: 67268-43-3
7-propargyloxy-4-methyl-2H-chromen-2-one

Guidance literature:: 7-hydroxy-4-methyl-chromen-2-one; With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

propargyl halide; In N,N-dimethyl-formamide; at 60 ℃; for 24h;
DOI:10.1039/d0cc04953k

Reference yield:

: 108-46-3
recorcinol

: 67268-43-3
7-propargyloxy-4-methyl-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid

2: potassium carbonate / acetone / 18 h / 50 °C

With sulfuric acid; potassium carbonate; In acetone; 1: |Pechmann Condensation;
DOI:10.1111/j.1747-0285.2012.01441.x