N-tert-Butyloxycarbonyl-L-phenylalanyl-DL-α-(tert-butyldiphenylsilyloxy)glycine ethyl ester

Base Information

Chemical Name:N-tert-Butyloxycarbonyl-L-phenylalanyl-DL-α-(tert-butyldiphenylsilyloxy)glycine ethyl ester
CAS No.:271581-13-6
Molecular Formula:C₃₄H₄₄N₂O₆Si
Molecular Weight:604.819
Hs Code.:

Synonyms:N-tert-Butyloxycarbonyl-L-phenylalanyl-DL-α-(tert-butyldiphenylsilyloxy)glycine ethyl ester

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Chemical Property of N-tert-Butyloxycarbonyl-L-phenylalanyl-DL-α-(tert-butyldiphenylsilyloxy)glycine ethyl ester

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Technology Process of N-tert-Butyloxycarbonyl-L-phenylalanyl-DL-α-(tert-butyldiphenylsilyloxy)glycine ethyl ester

There total 1 articles about N-tert-Butyloxycarbonyl-L-phenylalanyl-DL-α-(tert-butyldiphenylsilyloxy)glycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: (2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-hydroxy-acetic acid ethyl ester

: 271581-13-6
N-tert-Butyloxycarbonyl-L-phenylalanyl-DL-α-(tert-butyldiphenylsilyloxy)glycine ethyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1039/a907483j

Reference yield: 85.0%

: 271581-13-6
N-tert-Butyloxycarbonyl-L-phenylalanyl-DL-α-(tert-butyldiphenylsilyloxy)glycine ethyl ester

: 271581-14-7
N-tert-Butyloxycarbonyl-L-phenylalanyl-DL-α-(tert-butyldiphenylsilyloxy)glycine

Guidance literature:: With sodium hydroxide; water; In methanol; for 1h;
DOI:10.1039/a907483j

Reference yield:

: 271581-13-6
N-tert-Butyloxycarbonyl-L-phenylalanyl-DL-α-(tert-butyldiphenylsilyloxy)glycine ethyl ester

: N-Benzyl-(N-tert-butyloxycarbonyl-L-phenylalanyl-DL-α-hydroxy)glycinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / NaOH; water / methanol / 1 h

2: 45 percent / BOP; Et₃N / CH₂Cl₂

3: 66 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

With sodium hydroxide; tetrabutyl ammonium fluoride; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1: Hydrolysis / 2: Acylation / 3: Substitution;
DOI:10.1039/a907483j