Technology Process of Ppoc-Phe-D-Trp(Boc)-Leu-OMe
There total 9 articles about Ppoc-Phe-D-Trp(Boc)-Leu-OMe which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / 4-dimethylaminopyridine / acetonitrile / 2 h
2: 4.46 g / trifluoroacetic acid / CH2Cl2 / 1 h
3: 93 percent / CH2Cl2 / from -10 deg C to r.t.
4: 100 percent / hydrazine hydrate / methanol / 2 h / Ambient temperature
5: 1.) HCl, isopentyl nitrite; 2.) N-methyl-morpholine / 1.) DMF, dioxane, 30 min, -30 deg C; 2.) DMF, dioxane, 2 h, -15 deg C then r.t., pH 7.5, overnight
With
4-methyl-morpholine; hydrogenchloride; dmap; hydrazine hydrate; trifluoroacetic acid; isopentyl nitrite;
In
methanol; dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 93 percent / CH2Cl2 / from -10 deg C to r.t.
2: 100 percent / hydrazine hydrate / methanol / 2 h / Ambient temperature
3: 1.) HCl, isopentyl nitrite; 2.) N-methyl-morpholine / 1.) DMF, dioxane, 30 min, -30 deg C; 2.) DMF, dioxane, 2 h, -15 deg C then r.t., pH 7.5, overnight
With
4-methyl-morpholine; hydrogenchloride; hydrazine hydrate; isopentyl nitrite;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / 4-dimethylaminopyridine / acetonitrile / 2 h
2: 4.46 g / trifluoroacetic acid / CH2Cl2 / 1 h
3: 93 percent / CH2Cl2 / from -10 deg C to r.t.
4: 100 percent / hydrazine hydrate / methanol / 2 h / Ambient temperature
5: 1.) HCl, isopentyl nitrite; 2.) N-methyl-morpholine / 1.) DMF, dioxane, 30 min, -30 deg C; 2.) DMF, dioxane, 2 h, -15 deg C then r.t., pH 7.5, overnight
With
4-methyl-morpholine; hydrogenchloride; dmap; hydrazine hydrate; trifluoroacetic acid; isopentyl nitrite;
In
methanol; dichloromethane; acetonitrile;
