Methanesulfonic acid (1S,2S)-2-(tert-butyl-dimethyl-silanyloxy)-1-{2-[2-(4-chloro-phenyl)-benzooxazol-4-yl]-ethyl}-propyl ester

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Chemical Name:Methanesulfonic acid (1S,2S)-2-(tert-butyl-dimethyl-silanyloxy)-1-{2-[2-(4-chloro-phenyl)-benzooxazol-4-yl]-ethyl}-propyl ester
CAS No.:583873-70-5
Molecular Formula:C₂₅H₃₄ClNO₅SSi
Molecular Weight:524.153
Hs Code.:

Synonyms:Methanesulfonic acid (1S,2S)-2-(tert-butyl-dimethyl-silanyloxy)-1-{2-[2-(4-chloro-phenyl)-benzooxazol-4-yl]-ethyl}-propyl ester

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Chemical Property of Methanesulfonic acid (1S,2S)-2-(tert-butyl-dimethyl-silanyloxy)-1-{2-[2-(4-chloro-phenyl)-benzooxazol-4-yl]-ethyl}-propyl ester

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Technology Process of Methanesulfonic acid (1S,2S)-2-(tert-butyl-dimethyl-silanyloxy)-1-{2-[2-(4-chloro-phenyl)-benzooxazol-4-yl]-ethyl}-propyl ester

There total 5 articles about Methanesulfonic acid (1S,2S)-2-(tert-butyl-dimethyl-silanyloxy)-1-{2-[2-(4-chloro-phenyl)-benzooxazol-4-yl]-ethyl}-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(4-chlorophenyl)benzoxazole-4-carbaldehyde

: 583873-70-5
Methanesulfonic acid (1S,2S)-2-(tert-butyl-dimethyl-silanyloxy)-1-{2-[2-(4-chloro-phenyl)-benzooxazol-4-yl]-ethyl}-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -50 °C

1.2: 71.6 percent / hexane; tetrahydrofuran / 30 h / 0 - 20 °C

2.1: 77.4 percent / L-Selectride / tetrahydrofuran / 0.5 h / -20 °C

3.1: 100 percent / H₂ / Pd/C / ethyl acetate / 0.33 h / 20 °C / atmospheric pressure

4.1: triethylamine / CH₂Cl₂ / 1 h / 0 °C

With n-butyllithium; hydrogen; L-Selectride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; 1.2: Wittig-Horner reaction;
DOI:10.1021/jm050413g

Reference yield:

: (S)-4-(tert-butyldimethylsilyloxy)-1-[2-(4-chlorophenyl)-4-benzoxazolyl]-1-penten-3-one

: 583873-70-5
Methanesulfonic acid (1S,2S)-2-(tert-butyl-dimethyl-silanyloxy)-1-{2-[2-(4-chloro-phenyl)-benzooxazol-4-yl]-ethyl}-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77.4 percent / L-Selectride / tetrahydrofuran / 0.5 h / -20 °C

2: 100 percent / H₂ / Pd/C / ethyl acetate / 0.33 h / 20 °C / atmospheric pressure

3: triethylamine / CH₂Cl₂ / 1 h / 0 °C

With hydrogen; L-Selectride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm050413g

Reference yield:

: (3S,4S)-4-(tert-butyldimethylsilyloxy)-1-[2-(4-chlorophenyl)-4-benzoxazolyl]-1-penten-3-ol

: 583873-70-5
Methanesulfonic acid (1S,2S)-2-(tert-butyl-dimethyl-silanyloxy)-1-{2-[2-(4-chloro-phenyl)-benzooxazol-4-yl]-ethyl}-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / ethyl acetate / 0.33 h / 20 °C / atmospheric pressure

2: triethylamine / CH₂Cl₂ / 1 h / 0 °C

With hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jm050413g