6-(3-amino-4-methoxyphenyl)-2,3,5,6-tetrahydroimidazo<2,1-b>thiazole dihydrochloride

Base Information

Chemical Name:6-(3-amino-4-methoxyphenyl)-2,3,5,6-tetrahydroimidazo<2,1-b>thiazole dihydrochloride
CAS No.:145235-70-7
Molecular Formula:C₁₂H₁₅N₃OS*2ClH
Molecular Weight:322.258
Hs Code.:

Synonyms:6-(3-amino-4-methoxyphenyl)-2,3,5,6-tetrahydroimidazo<2,1-b>thiazole dihydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(3-amino-4-methoxyphenyl)-2,3,5,6-tetrahydroimidazo<2,1-b>thiazole dihydrochloride

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Technology Process of 6-(3-amino-4-methoxyphenyl)-2,3,5,6-tetrahydroimidazo<2,1-b>thiazole dihydrochloride

There total 4 articles about 6-(3-amino-4-methoxyphenyl)-2,3,5,6-tetrahydroimidazo<2,1-b>thiazole dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 145235-78-5
6-(4-methoxy-3-nitrophenyl)-2,3,5,6-tetrahydroimidazo<2,1-b>thiazole hydrochloride

: 145235-70-7
6-(3-amino-4-methoxyphenyl)-2,3,5,6-tetrahydroimidazo<2,1-b>thiazole dihydrochloride

Guidance literature:: With hydrogenchloride; tin(ll) chloride; 1.) 40 deg C, 1 h, 2.) 70 deg C, 1.5 h;
DOI:10.1016/0223-5234(92)90184-3

Reference yield:

: 65447-49-6
2-bromo-1-(3-nitro-4-methoxyphenyl)ethan-1-one

: 145235-70-7
6-(3-amino-4-methoxyphenyl)-2,3,5,6-tetrahydroimidazo<2,1-b>thiazole dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / acetone / 1.) RT, 1 h, 2.) reflux, 0.5 h

2: NaBH₄ / methanol / 2 h / Ambient temperature

3: 34 percent / conc. H₂SO₄

4: 49 percent / SnCl₂*2H₂O, conc. HCl / 1.) 40 deg C, 1 h, 2.) 70 deg C, 1.5 h

With hydrogenchloride; sodium tetrahydroborate; sulfuric acid; tin(ll) chloride; In methanol; acetone;
DOI:10.1016/0223-5234(92)90184-3

Reference yield:

: 6277-38-9
1-(4-methoxy-3-nitrophenyl)ethanone

: 145235-70-7
6-(3-amino-4-methoxyphenyl)-2,3,5,6-tetrahydroimidazo<2,1-b>thiazole dihydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: Br₂ / CHCl₃ / 1.25 h / 0 - 20 °C

2: 83 percent / acetone / 1.) RT, 1 h, 2.) reflux, 0.5 h

3: NaBH₄ / methanol / 2 h / Ambient temperature

4: 34 percent / conc. H₂SO₄

5: 49 percent / SnCl₂*2H₂O, conc. HCl / 1.) 40 deg C, 1 h, 2.) 70 deg C, 1.5 h

With hydrogenchloride; sodium tetrahydroborate; sulfuric acid; bromine; tin(ll) chloride; In methanol; chloroform; acetone;
DOI:10.1016/0223-5234(92)90184-3