6-bromo-3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine

Base Information

Chemical Name:6-bromo-3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine
CAS No.:1200130-00-2
Molecular Formula:C₂₂H₂₁BrN₄
Molecular Weight:421.34
Hs Code.:

Synonyms:6-bromo-3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine

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Chemical Property of 6-bromo-3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine

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Technology Process of 6-bromo-3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine

There total 9 articles about 6-bromo-3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 6′-bromo-2-fluoro-5-(4-(piperidin-1-ylmethyl)phenyl)-[3,4′-bipyridin]-3′-amine

: 1200130-00-2
6-bromo-3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b00464

Reference yield:

: 1200130-82-0
6-bromo-4-iodonicotinic acid

: 1200130-00-2
6-bromo-3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine

Guidance literature:: Multi-step reaction with 4 steps

1: diphenylphosphoranyl azide; triethylamine / toluene / 3 h / 110 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: potassium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 4 h / 90 °C

4: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; diphenylphosphoranyl azide; sodium hexamethyldisilazane; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/acs.jmedchem.5b00464

Reference yield:

: 1200130-83-1
tert-butyl (6-bromo-4-iodopyridin-3-yl)carbamate

: 1200130-00-2
6-bromo-3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]dipyridine

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: potassium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 4 h / 90 °C

3: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; sodium hexamethyldisilazane; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/acs.jmedchem.5b00464