(S)-3-Benzyloxy-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propionaldehyde

Base Information

Chemical Name:(S)-3-Benzyloxy-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propionaldehyde
CAS No.:895532-74-8
Molecular Formula:C₁₇H₂₄O₄
Molecular Weight:292.375
Hs Code.:

Synonyms:(S)-3-Benzyloxy-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propionaldehyde

Suppliers and Price of (S)-3-Benzyloxy-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propionaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-Benzyloxy-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propionaldehyde

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-3-Benzyloxy-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propionaldehyde

There total 6 articles about (S)-3-Benzyloxy-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 895532-73-7
(S)-3-(benzyloxy)-3-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethylpropan-1-ol

: 895532-74-8
(S)-3-Benzyloxy-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propionaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃; for 3h;
DOI:10.1021/ol060827j

Reference yield:

: 3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester

: 895532-74-8
(S)-3-Benzyloxy-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propionaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / N-methylmorpholine N-oxide monohydrate; tetrapropylammonium perruthenate; molecular sieves 4 Angstroem / acetonitrile; CH₂Cl₂ / 0.5 h

2: zinc borohydride / diethyl ether / 1 h / -100 - -40 °C

3: 91 percent / sodium hydride / dimethylformamide / 0 - 20 °C

4: 100 percent / lithium aluminum hydride / tetrahydrofuran / 8 h / 0 - 20 °C

5: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / 3 h / -78 °C

With lithium aluminium tetrahydride; tetrapropylammonium perruthennate; oxalyl dichloride; 4 A molecular sieve; zinc borohydride; sodium hydride; dimethyl sulfoxide; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 5: Swern oxidation;
DOI:10.1021/jo070861r

Reference yield:

: 895532-67-9
(R)-methyl 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-3-oxopropanoate

: 895532-74-8
(S)-3-Benzyloxy-3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-propionaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: zinc borohydride / diethyl ether / 1 h / -100 - -40 °C

2: 91 percent / sodium hydride / dimethylformamide / 0 - 20 °C

3: 100 percent / lithium aluminum hydride / tetrahydrofuran / 8 h / 0 - 20 °C

4: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / 3 h / -78 °C

With lithium aluminium tetrahydride; oxalyl dichloride; zinc borohydride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 4: Swern oxidation;
DOI:10.1021/jo070861r