(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-methanol

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Chemical Name:(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-methanol
CAS No.:1426082-14-5
Molecular Formula:C₂₇H₂₆N₄O₂S
Molecular Weight:470.595
Hs Code.:

Synonyms:(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-methanol

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Chemical Property of (6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-methanol

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Technology Process of (6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-methanol

There total 9 articles about (6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1426082-13-4
6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophene-3-carbaldehyde

: 1426082-14-5
(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-methanol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2012.12.035

Reference yield:

: 1251931-22-2
{2-[4-(4-bromo-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-2-yl)-phenoxy]-ethyl}-dimethyl-amine

: 1426082-14-5
(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / 60 °C

2: potassium carbonate; triphenylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / Reflux

3: sodium tetrahydroborate / ethanol / 2 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; water; palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; ethanol; water; 2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.12.035

Reference yield:

: 57848-46-1
4-bromo-2-fluorobenzaldehyde

: 1426082-14-5
(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-methanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 5.5 h / 60 °C

2.1: potassium hydroxide / water; ethanol / 1.5 h / Reflux

3.1: copper; quinoline / 2 h / 185 °C

4.1: N-Bromosuccinimide; acetic acid / chloroform / 20 °C / Cooling with ice

5.1: n-butyllithium / diethyl ether; hexane / 1.25 h / -40 °C

5.2: 4 h / -70 °C

6.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 90 °C

7.1: potassium carbonate; triphenylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / Reflux

8.1: sodium tetrahydroborate / ethanol / 2 h / 20 °C

With quinoline; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; potassium acetate; palladium diacetate; copper; potassium carbonate; acetic acid; triphenylphosphine; potassium hydroxide; In 1,2-dimethoxyethane; diethyl ether; ethanol; hexane; chloroform; water; N,N-dimethyl-formamide; 7.1: |Suzuki Coupling;
DOI:10.1016/j.bmc.2012.12.035