ethyl 5,6-dimethoxy-1-oxo-2-(3-o-tolylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

Base Information

Chemical Name:ethyl 5,6-dimethoxy-1-oxo-2-(3-o-tolylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate
CAS No.:1609250-11-4
Molecular Formula:C₂₄H₂₄O₅
Molecular Weight:392.452
Hs Code.:

Synonyms:ethyl 5,6-dimethoxy-1-oxo-2-(3-o-tolylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

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Chemical Property of ethyl 5,6-dimethoxy-1-oxo-2-(3-o-tolylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

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Technology Process of ethyl 5,6-dimethoxy-1-oxo-2-(3-o-tolylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

There total 3 articles about ethyl 5,6-dimethoxy-1-oxo-2-(3-o-tolylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 615-37-2
ortho-methylphenyl iodide

: 1465900-92-8
ethyl 5,6-dimethoxy-1-oxo-2-(prop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

: 1609250-11-4
ethyl 5,6-dimethoxy-1-oxo-2-(3-o-tolylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: ortho-methylphenyl iodide; With copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine; In ethanol; for 0.5h; Inert atmosphere;

ethyl 5,6-dimethoxy-1-oxo-2-(prop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate; In ethanol; for 3h; Reflux; Inert atmosphere;
DOI:10.1080/00397911.2013.860554

Reference yield:

: 53295-44-6
5,6-(dimethoxy)-2-(ethoxycarbonyl)-indan-1-one

: 1609250-11-4
ethyl 5,6-dimethoxy-1-oxo-2-(3-o-tolylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon; triethylamine / ethanol / 0.5 h / Inert atmosphere

2.2: 3 h / Reflux; Inert atmosphere

With copper(l) iodide; palladium 10% on activated carbon; potassium carbonate; triethylamine; triphenylphosphine; In ethanol; acetone;
DOI:10.1080/00397911.2013.860554

Reference yield:

: 2107-69-9
5,6-dimethoxy-1-indanone

: 1609250-11-4
ethyl 5,6-dimethoxy-1-oxo-2-(3-o-tolylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil / 2 h / 80 °C / Inert atmosphere; Reflux

2.1: potassium carbonate / acetone / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon; triethylamine / ethanol / 0.5 h / Inert atmosphere

3.2: 3 h / Reflux; Inert atmosphere

With copper(l) iodide; palladium 10% on activated carbon; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; In ethanol; acetone; mineral oil;
DOI:10.1080/00397911.2013.860554