4-(3-(5-fluoro-2-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)thiazol-2-amine

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Chemical Name:4-(3-(5-fluoro-2-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)thiazol-2-amine
CAS No.:1355335-93-1
Molecular Formula:C₂₅H₂₁FN₆O₂S
Molecular Weight:488.545
Hs Code.:

Synonyms:4-(3-(5-fluoro-2-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)thiazol-2-amine

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Chemical Property of 4-(3-(5-fluoro-2-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)thiazol-2-amine

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(3-(5-fluoro-2-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)thiazol-2-amine

There total 5 articles about 4-(3-(5-fluoro-2-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1355335-92-0
4-(3-bromo-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)thiazol-2-amine

: 179897-94-0
(5-fluoro-2-methoxyphenyl)boronic acid

: 1355335-93-1
4-(3-(5-fluoro-2-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)thiazol-2-amine

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 120 ℃; Inert atmosphere;

Reference yield:

: 1355249-61-4
ethyl 3-bromo-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylate

: 1355335-93-1
4-(3-(5-fluoro-2-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / methanol / 2 h / Inert atmosphere; Reflux

1.2: 20 °C / pH 2 - 3

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3.1: acetonitrile / 0 - 20 °C / Inert atmosphere

3.2: 6 h / 0 - 20 °C

4.1: ethanol / 1 h / Inert atmosphere; Reflux

5.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere

With oxalyl dichloride; sodium hydrogencarbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1355335-89-5
3-bromo-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylic acid

: 1355335-93-1
4-(3-(5-fluoro-2-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: acetonitrile / 0 - 20 °C / Inert atmosphere

2.2: 6 h / 0 - 20 °C

3.1: ethanol / 1 h / Inert atmosphere; Reflux

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 120 °C / Inert atmosphere

With oxalyl dichloride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;