N-(4-nitrocyclohexyl)-4-<(trifluoroacetyl)amino>benzeneacetamide

Base Information

• Chemical Name: N-(4-nitrocyclohexyl)-4-<(trifluoroacetyl)amino>benzeneacetamide
• CAS No.: 130468-93-8
• Molecular Formula: C₁₆H₁₈F₃N₃O₄
• Molecular Weight: 373.332
• Mol file: 130468-93-8.mol

Synonyms:N-(4-nitrocyclohexyl)-4-<(trifluoroacetyl)amino>benzeneacetamide

Chemical Property of N-(4-nitrocyclohexyl)-4-<(trifluoroacetyl)amino>benzeneacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-nitrocyclohexyl)-4-<(trifluoroacetyl)amino>benzeneacetamide

There total 3 articles about N-(4-nitrocyclohexyl)-4-<(trifluoroacetyl)amino>benzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-<(trifluoroacetyl)amino>benzeneacetyl chloride (113180-63-5) + 4-nitrocyclohexanamine monohydrobromide (121936-58-1) → N-(4-nitrocyclohexyl)-4-<(trifluoroacetyl)amino>benzeneacetamide (130468-93-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 45 ℃; for 3h;

DOI:10.1021/ja00001a042

Reference yield:

4-aminophenylacetic acid (1197-55-3) → N-(4-nitrocyclohexyl)-4-<(trifluoroacetyl)amino>benzeneacetamide (130468-93-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / sodium carbonate, water / acetonitrile / 0.17 h / 0 °C

2: 98 percent / thionyl chloride / 5 h / 55 °C

3: 68 percent / triethylamine, 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 3 h / 45 °C

With dmap; thionyl chloride; water; sodium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/ja00001a042

Reference yield:

4-<(trifluoroacetyl)amino>benzeneacetic acid (105113-62-0) → N-(4-nitrocyclohexyl)-4-<(trifluoroacetyl)amino>benzeneacetamide (130468-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / thionyl chloride / 5 h / 55 °C

2: 68 percent / triethylamine, 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 3 h / 45 °C

With dmap; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/ja00001a042

upstream raw materials:

4-<(trifluoroacetyl)amino>benzeneacetyl chloride

4-nitrocyclohexanamine monohydrobromide

4-aminophenylacetic acid

4-<(trifluoroacetyl)amino>benzeneacetic acid

Downstream raw materials:

5-<<4-<2-<(4-nitrocyclohexyl)amino>-2-oxoethyl>phenyl>amino>-5-oxopentanoic acid

N-(4-nitrocyclohexyl)-4-aminobenzeneacetamide