{5-[2-(6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetylamino]-pentyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {5-[2-(6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetylamino]-pentyl}-carbamic acid tert-butyl ester
• CAS No.: 259730-86-4
• Molecular Formula: C₃₀H₃₃BrN₄O₄
• Molecular Weight: 593.52

Synonyms:{5-[2-(6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetylamino]-pentyl}-carbamic acid tert-butyl ester

Chemical Property of {5-[2-(6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetylamino]-pentyl}-carbamic acid tert-butyl ester

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Technology Process of {5-[2-(6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetylamino]-pentyl}-carbamic acid tert-butyl ester

There total 1 articles about {5-[2-(6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetylamino]-pentyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-tert-butoxycarbonylamino-1-aminopentane (51644-96-3) + (6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetic acid (259730-85-3) → {5-[2-(6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetylamino]-pentyl}-carbamic acid tert-butyl ester (259730-86-4)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;

DOI:10.1016/S0960-894X(99)00584-3

Reference yield:

{5-[2-(6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetylamino]-pentyl}-carbamic acid tert-butyl ester (259730-86-4) → N-(5-amino-pentyl)-2-(2-naphthalen-2-yl-4-oxo-6-phenyl-4H-quinazolin-3-yl)-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: Pd(PPh₃)4; Na₂CO₃

2: HCl

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; 1: Arylation / 2: Acidolysis;

DOI:10.1016/S0960-894X(99)00584-3

Reference yield:

{5-[2-(6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetylamino]-pentyl}-carbamic acid tert-butyl ester (259730-86-4) + phenylboronic acid (98-80-6) → {5-[2-(2-naphthalen-2-yl-4-oxo-6-phenyl-4H-quinazolin-3-yl)-acetylamino]-pentyl}-carbamic acid tert-butyl ester (259730-80-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate;

DOI:10.1016/S0960-894X(99)00584-3

upstream raw materials:

5-tert-butoxycarbonylamino-1-aminopentane

(6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetic acid

Downstream raw materials:

{5-[2-(2-naphthalen-2-yl-4-oxo-6-phenyl-4H-quinazolin-3-yl)-acetylamino]-pentyl}-carbamic acid tert-butyl ester

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