Technology Process of (R)-4-Benzyl-3-[(3aR,4R,5R,7aS)-5-(3-hydroxy-propyl)-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carbonyl]-oxazolidin-2-one
There total 10 articles about (R)-4-Benzyl-3-[(3aR,4R,5R,7aS)-5-(3-hydroxy-propyl)-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carbonyl]-oxazolidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: pyridine / 14 h / Ambient temperature
2: 74 percent / Li2CuCl4 / 2 h / -30 °C
3: AcOH / H2O; tetrahydrofuran / 4 h / 80 °C
4: t-BuOK / tetrahydrofuran / 5 h / -20 °C
5: 57 percent / 10percent NaOH / methanol; tetrahydrofuran / 10 h / Ambient temperature
6: (COCl)2 / toluene / 20 h / Ambient temperature
7: n-BuLi / tetrahydrofuran / 1.5 h / -78 °C
8: 57 percent / 1.3 eq. Me2AlCl / CH2Cl2 / 5 h / -30 °C
9: 100 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.25 h / 0 °C
With
pyridine; sodium hydroxide; n-butyllithium; oxalyl dichloride; ammonium cerium(IV) nitrate; potassium tert-butylate; dimethylaluminum chloride; acetic acid;
dilithium tetrachlorocuprate;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)99589-3
- Guidance literature:
-
Multi-step reaction with 10 steps
1: diisobutylalumnum hydride / diethyl ether / 1 h / -78 °C
2: pyridine / 14 h / Ambient temperature
3: 74 percent / Li2CuCl4 / 2 h / -30 °C
4: AcOH / H2O; tetrahydrofuran / 4 h / 80 °C
5: t-BuOK / tetrahydrofuran / 5 h / -20 °C
6: 57 percent / 10percent NaOH / methanol; tetrahydrofuran / 10 h / Ambient temperature
7: (COCl)2 / toluene / 20 h / Ambient temperature
8: n-BuLi / tetrahydrofuran / 1.5 h / -78 °C
9: 57 percent / 1.3 eq. Me2AlCl / CH2Cl2 / 5 h / -30 °C
10: 100 percent / ceric ammonium nitrate / acetonitrile; H2O / 0.25 h / 0 °C
With
pyridine; sodium hydroxide; n-butyllithium; oxalyl dichloride; ammonium cerium(IV) nitrate; potassium tert-butylate; dimethylaluminum chloride; diisobutylaluminium hydride; acetic acid;
dilithium tetrachlorocuprate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene; acetonitrile;
DOI:10.1016/S0040-4039(00)99589-3
![(R)-4-Benzyl-3-{(3aR,4R,5R,7aS)-5-[3-(4-methoxy-phenoxy)-propyl]-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carbonyl}-oxazolidin-2-one](/Databaselist/images/loading.webp)
