3-[4-(7-ethoxycarbonylmethoxy-naphthalen-2-yloxy)-phenyl]-but-2-enoic acid ethyl ester

Base Information

• Chemical Name: 3-[4-(7-ethoxycarbonylmethoxy-naphthalen-2-yloxy)-phenyl]-but-2-enoic acid ethyl ester
• CAS No.: 1189339-35-2
• Molecular Formula: C₂₆H₂₆O₆
• Molecular Weight: 434.489
• Mol file: 1189339-35-2.mol

Synonyms:3-[4-(7-ethoxycarbonylmethoxy-naphthalen-2-yloxy)-phenyl]-but-2-enoic acid ethyl ester

Chemical Property of 3-[4-(7-ethoxycarbonylmethoxy-naphthalen-2-yloxy)-phenyl]-but-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(7-ethoxycarbonylmethoxy-naphthalen-2-yloxy)-phenyl]-but-2-enoic acid ethyl ester

There total 5 articles about 3-[4-(7-ethoxycarbonylmethoxy-naphthalen-2-yloxy)-phenyl]-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + [7-(4-acetyl-phenoxy)-naphthalen-2-yloxy]-acetic acid ethyl ester (1189339-34-1) → 3-[4-(7-ethoxycarbonylmethoxy-naphthalen-2-yloxy)-phenyl]-but-2-enoic acid ethyl ester (1189339-35-2)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1h; Inert atmosphere;

[7-(4-acetyl-phenoxy)-naphthalen-2-yloxy]-acetic acid ethyl ester; In tetrahydrofuran; mineral oil; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.bmcl.2021.128305

Reference yield: 83.87%

[7-(4-acetyl-phenoxy)-naphthalen-2-yloxy]-acetic acid ethyl ester (1189339-34-1) → 3-[4-(7-ethoxycarbonylmethoxy-naphthalen-2-yloxy)-phenyl]-but-2-enoic acid ethyl ester (1189339-35-2)

Guidance literature:

With diethoxyphosphoryl-acetic acid ethyl ester; sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 20h;

Reference yield:

1-[4-(7-hydroxy-naphthalen-2-yloxy)-phenyl]-ethanone (1189339-33-0) → 3-[4-(7-ethoxycarbonylmethoxy-naphthalen-2-yloxy)-phenyl]-but-2-enoic acid ethyl ester (1189339-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 8 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 20 h / 20 °C / Inert atmosphere

With sodium hydride; potassium carbonate; In tetrahydrofuran; acetone; mineral oil;

DOI:10.1016/j.bmcl.2021.128305

upstream raw materials:

[7-(4-acetyl-phenoxy)-naphthalen-2-yloxy]-acetic acid ethyl ester

1-[4-(7-hydroxy-naphthalen-2-yloxy)-phenyl]-ethanone

1-(4-fluorophenyl)ethanone

2,7-Dihydroxynaphthalene

Downstream raw materials:

3-{4-[7-(2-hydroxy-ethoxy)-naphthalen-2-yloxy]-phenyl}-but-2-en-1-ol