4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride

Base Information

• Chemical Name: 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride
• CAS No.: 1314032-66-0
• Molecular Formula: C₁₈H₁₃N₄O₃S*Cl
• Molecular Weight: 400.845
• Mol file: 1314032-66-0.mol

Synonyms:4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride

Chemical Property of 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride

There total 4 articles about 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.7%

5-nitrofuran-2-carboxylic chloride (25084-14-4) + 1,4-diphenylthiosemicarbazide (1768-59-8) → 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride (1314032-66-0)

Guidance literature:

In 1,4-dioxane; at 20 ℃; for 24h;

DOI:10.3390/molecules16032023

Reference yield:

5-nitro-2-furoic acid (645-12-5) → 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride (1314032-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 60 °C

2: 1,4-dioxane; water / 20 °C

With thionyl chloride; N,N-dimethyl-formamide; In 1,4-dioxane; water;

DOI:10.3390/molecules16032023

Reference yield:

phenyl isothiocyanate (103-72-0) → 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride (1314032-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 2.17 h / 90 °C

2: 1,4-dioxane; water / 20 °C

In 1,4-dioxane; water; toluene;

DOI:10.3390/molecules16032023

upstream raw materials:

5-nitro-2-furoic acid

5-nitrofuran-2-carboxylic chloride

1,4-diphenylthiosemicarbazide

phenyl isothiocyanate

Downstream raw materials:

1,4-diphenyl-5-(5-nitro-2-furanyl)-1,3,4-triazolium-2-thiol chloride