N-{5-[(2-chloro-4-pyrimidinyl)ethynyl]-2-fluorophenyl}-2,2,2-trifluoroacetamide

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Chemical Name:N-{5-[(2-chloro-4-pyrimidinyl)ethynyl]-2-fluorophenyl}-2,2,2-trifluoroacetamide
CAS No.:895637-02-2
Molecular Formula:C₁₄H₆ClF₄N₃O
Molecular Weight:343.668
Hs Code.:

Synonyms:N-{5-[(2-chloro-4-pyrimidinyl)ethynyl]-2-fluorophenyl}-2,2,2-trifluoroacetamide

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Chemical Property of N-{5-[(2-chloro-4-pyrimidinyl)ethynyl]-2-fluorophenyl}-2,2,2-trifluoroacetamide

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Technology Process of N-{5-[(2-chloro-4-pyrimidinyl)ethynyl]-2-fluorophenyl}-2,2,2-trifluoroacetamide

There total 2 articles about N-{5-[(2-chloro-4-pyrimidinyl)ethynyl]-2-fluorophenyl}-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 895637-01-1
N-(5-ethynyl-2-fluorophenyl)-2,2,2-trifluoroacetamide

: 895637-02-2
N-{5-[(2-chloro-4-pyrimidinyl)ethynyl]-2-fluorophenyl}-2,2,2-trifluoroacetamide

Guidance literature:: 2,6-Dichloropyrimidine; With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 60 ℃; for 0.5h;

N-(5-ethynyl-2-fluorophenyl)-2,2,2-trifluoroacetamide; In tetrahydrofuran; at 60 ℃; for 16h; Product distribution / selectivity; Heating / reflux;

Reference yield: 29.0%

: 3934-20-1
2,6-Dichloropyrimidine

: 895637-01-1
N-(5-ethynyl-2-fluorophenyl)-2,2,2-trifluoroacetamide

: 895637-02-2
N-{5-[(2-chloro-4-pyrimidinyl)ethynyl]-2-fluorophenyl}-2,2,2-trifluoroacetamide

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 60 ℃; for 16h;