diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate

Base Information

Chemical Name:diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate
CAS No.:150585-92-5
Molecular Formula:C₂₃H₂₇N₅O₆
Molecular Weight:469.497
Hs Code.:

Synonyms:diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate

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Chemical Property of diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate

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Technology Process of diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate

There total 4 articles about diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 4-(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-benzoic acid

: 150585-92-5
diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1248/cpb.49.1280

Reference yield:

: 134372-99-9
3-(4-<2,2-dimethylethyl>carboxyphenyl)-1-propanal

: 150585-92-5
diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / 5,5-dibromobarbituric acid / diethyl ether / 64 h / 20 °C

2: 41 percent / K₂CO₃ / dimethylsulfoxide / 4 h / 20 °C

3: trifluoroacetic acid / CH₂Cl₂ / 4 h / 20 °C

4: 100 percent / diethyl cyanophosphonate; Et₃N / dimethylformamide / 18 h / 20 °C

With 5,5-dibromobarbituric acid; diethyl cyanophosphonate; potassium carbonate; triethylamine; trifluoroacetic acid; In diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.1280

Reference yield:

: 389625-30-3
4-(2-bromo-3-oxo-propyl)-benzoic acid tert-butyl ester

: 150585-92-5
diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / K₂CO₃ / dimethylsulfoxide / 4 h / 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 4 h / 20 °C

3: 100 percent / diethyl cyanophosphonate; Et₃N / dimethylformamide / 18 h / 20 °C

With diethyl cyanophosphonate; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.1280