3-benzyloxy-1-hydroxy-7,8,10,11,14,15-hexahydro-6H-5-oxa-8,15-diaza-benzocyclotetradecene-9,16-dione

Base Information

• Chemical Name: 3-benzyloxy-1-hydroxy-7,8,10,11,14,15-hexahydro-6H-5-oxa-8,15-diaza-benzocyclotetradecene-9,16-dione
• CAS No.: 884864-59-9
• Molecular Formula: C₂₂H₂₄N₂O₅
• Molecular Weight: 396.443

Synonyms:3-benzyloxy-1-hydroxy-7,8,10,11,14,15-hexahydro-6H-5-oxa-8,15-diaza-benzocyclotetradecene-9,16-dione

Chemical Property of 3-benzyloxy-1-hydroxy-7,8,10,11,14,15-hexahydro-6H-5-oxa-8,15-diaza-benzocyclotetradecene-9,16-dione

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Technology Process of 3-benzyloxy-1-hydroxy-7,8,10,11,14,15-hexahydro-6H-5-oxa-8,15-diaza-benzocyclotetradecene-9,16-dione

There total 8 articles about 3-benzyloxy-1-hydroxy-7,8,10,11,14,15-hexahydro-6H-5-oxa-8,15-diaza-benzocyclotetradecene-9,16-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-allyl-4-benzyloxy-2-hydroxy-6-(2-pent-4-enoylamino-ethoxy)-benzamide (884864-55-5) → 3-benzyloxy-1-hydroxy-7,8,10,11,14,15-hexahydro-6H-5-oxa-8,15-diaza-benzocyclotetradecene-9,16-dione (884864-59-9)

Guidance literature:

Cl₂Ru=CHPh(PCy)3; In dichloromethane; for 2h; Heating;

DOI:10.1016/j.tetlet.2006.01.117

Reference yield:

acide 2,4,6-trihydroxybenzoique (83-30-7) → 3-benzyloxy-1-hydroxy-7,8,10,11,14,15-hexahydro-6H-5-oxa-8,15-diaza-benzocyclotetradecene-9,16-dione (884864-59-9)

Guidance literature:

Multi-step reaction with 8 steps

1: trifluoroacetic acid; trifluoroacetic anhydride

2: 60 percent / Cl₂Ru=CHPh(PCy)3 / CH₂Cl₂ / 2 h / Heating

With trifluoroacetic acid; trifluoroacetic anhydride; Cl₂Ru=CHPh(PCy)3; In dichloromethane; 2: Mitsunobu reaction / 3: Mitsunobu reaction;

DOI:10.1016/j.tetlet.2006.01.117

Reference yield:

N-allyl-2-(2-amino-ethoxy)-4-benzyloxy-6-hydroxy-benzamide → 3-benzyloxy-1-hydroxy-7,8,10,11,14,15-hexahydro-6H-5-oxa-8,15-diaza-benzocyclotetradecene-9,16-dione (884864-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / Cl₂Ru=CHPh(PCy)3 / CH₂Cl₂ / 2 h / Heating

Cl₂Ru=CHPh(PCy)3; In dichloromethane;

DOI:10.1016/j.tetlet.2006.01.117

upstream raw materials:

N-allyl-4-benzyloxy-2-hydroxy-6-(2-pent-4-enoylamino-ethoxy)-benzamide

acide 2,4,6-trihydroxybenzoique

5,7-dihydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

7-(benzyloxy)-5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

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