(hexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

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Chemical Name:(hexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone
CAS No.:1293284-67-9
Molecular Formula:C₁₆H₁₉N₅O
Molecular Weight:297.36
Hs Code.:

Synonyms:(hexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

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Chemical Property of (hexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

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Technology Process of (hexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

There total 5 articles about (hexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

: 5-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylic acid tert-butyl ester

: 1293284-67-9
(hexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Guidance literature:: With hydrogenchloride; In dichloromethane; ethyl acetate; at 20 ℃; for 1h;

Reference yield:

: 956317-36-5
2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

: 1293284-67-9
(hexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride; pyridine / dichloromethane / 3 h / Reflux

2: triethylamine / dichloromethane / 12 h / 20 °C / Cooling with ice

3: hydrogenchloride / dichloromethane; ethyl acetate / 1 h / 20 °C

With pyridine; hydrogenchloride; thionyl chloride; triethylamine; In dichloromethane; ethyl acetate;

Reference yield:

: 52548-14-8
2-iodoyl-5-methylbenzoic acid

: 1293284-67-9
(hexahydropyrrolo[3,4-c]pyrrole-2(1H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; copper(l) iodide / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

2: thionyl chloride; pyridine / dichloromethane / 3 h / Reflux

3: triethylamine / dichloromethane / 12 h / 20 °C / Cooling with ice

4: hydrogenchloride / dichloromethane; ethyl acetate / 1 h / 20 °C

With pyridine; hydrogenchloride; copper(l) iodide; thionyl chloride; caesium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;