methyl 2-(4-(4-amino-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

Base Information

Chemical Name:methyl 2-(4-(4-amino-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate
CAS No.:1080522-01-5
Molecular Formula:C₁₉H₁₇F₃N₂O₄
Molecular Weight:394.35
Hs Code.:

Synonyms:methyl 2-(4-(4-amino-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

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Chemical Property of methyl 2-(4-(4-amino-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

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Technology Process of methyl 2-(4-(4-amino-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

There total 5 articles about methyl 2-(4-(4-amino-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080522-00-4
C₁₉H₁₅F₃N₂O₆

: 1080522-01-5
methyl 2-(4-(4-amino-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1h;

Reference yield:

: 1080521-94-3
methyl 2-(4-(2-bromo-4-nitro-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

: 1080522-01-5
methyl 2-(4-(4-amino-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / acetonitrile / 20 °C

2: copper(l) iodide; palladium dichloride / N,N-dimethyl-formamide / 1 h / 80 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

With dmap; hydrogen; trifluoroacetic acid; copper(l) iodide; palladium 10% on activated carbon; palladium dichloride; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1080523-14-3
methyl 2-(3-methoxy-4-(4-nitro-2-oxoindolin-5-yloxy)phenyl)acetate

: 1080522-01-5
methyl 2-(4-(4-amino-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 1 h / 90 °C

1.2: 2 h / 90 °C

1.3: pH 8

2.1: dmap / acetonitrile / 20 °C

3.1: copper(l) iodide; palladium dichloride / N,N-dimethyl-formamide / 1 h / 80 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

With dmap; hydrogen; trifluoroacetic acid; phosphorus(V) oxybromide; copper(l) iodide; palladium 10% on activated carbon; palladium dichloride; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;