7-(2-(4-[(2-t-butylaminosulfonyl)phenyl]benzoylamino)phenoxy)isoquinoline

Base Information

Chemical Name:7-(2-(4-[(2-t-butylaminosulfonyl)phenyl]benzoylamino)phenoxy)isoquinoline
CAS No.:330942-76-2
Molecular Formula:C₃₂H₂₉N₃O₄S
Molecular Weight:551.666
Hs Code.:

Synonyms:7-(2-(4-[(2-t-butylaminosulfonyl)phenyl]benzoylamino)phenoxy)isoquinoline

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Chemical Property of 7-(2-(4-[(2-t-butylaminosulfonyl)phenyl]benzoylamino)phenoxy)isoquinoline

Chemical Property:

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Technology Process of 7-(2-(4-[(2-t-butylaminosulfonyl)phenyl]benzoylamino)phenoxy)isoquinoline

There total 6 articles about 7-(2-(4-[(2-t-butylaminosulfonyl)phenyl]benzoylamino)phenoxy)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 330943-14-1
7-(2-aminophenoxy)isoquinoline

: 309930-58-3
4-{2-{[(tert-butyl)amino}sulfonyl}phenyl}benzoic acid

: 330942-76-2
7-(2-(4-[(2-t-butylaminosulfonyl)phenyl]benzoylamino)phenoxy)isoquinoline

Guidance literature:: With triethanolamine; In N,N-dimethyl-formamide;

Reference yield:

: 7651-83-4
isoquinolin-7-ol

: 330942-76-2
7-(2-(4-[(2-t-butylaminosulfonyl)phenyl]benzoylamino)phenoxy)isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide

2: SnCl₂*2H₂O / ethyl acetate

3: BOP; Et₃N / dimethylformamide

With potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; tin(ll) chloride; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00234-2

Reference yield:

: 14047-29-1
4-carboxyphenylboronic acid

: 330942-76-2
7-(2-(4-[(2-t-butylaminosulfonyl)phenyl]benzoylamino)phenoxy)isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: PdCl₂(PPh₃)2; K₂CO₃ / dioxane; H₂O

2: BOP; Et₃N / dimethylformamide

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00234-2