5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophene-2-carbaldehyde

Base Information

• Chemical Name: 5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophene-2-carbaldehyde
• CAS No.: 866852-05-3
• Molecular Formula: C₃₆H₃₆N₄O₃S
• Molecular Weight: 604.773
• Mol file: 866852-05-3.mol

Synonyms:5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophene-2-carbaldehyde

Chemical Property of 5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophene-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophene-2-carbaldehyde

There total 1 articles about 5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-[(4-methyl-1-piperazinyl)methyl]-3-(2-thienyl)-1,4-dihydroindeno[1,2-c]pyrazole (866849-66-3) → 5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophene-2-carbaldehyde (866852-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: 70 percent / tetrahydrofuran / -78 - 20 °C

2.1: 80 percent / Et₃N / tetrahydrofuran / 50 °C

With n-butyllithium; triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.05.066

Reference yield: 65.0%

5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophene-2-carbaldehyde (866852-05-3) → {5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophen-2-yl}-methanol (866852-59-7)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2006.05.066

Reference yield:

5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophene-2-carbaldehyde (866852-05-3) → 1-{5-[7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophen-2-ylmethyl}-3-o-tolyl-urea

Guidance literature:

Multi-step reaction with 5 steps

1.1: 65 percent / sodium borohydride / methanol; tetrahydrofuran / 0 - 20 °C

2.1: 95 percent / diphenyl phosphorazidate; DBU / tetrahydrofuran / 0 - 20 °C

3.1: PPh₃ / tetrahydrofuran / 40 °C

3.2: 96 percent / H₂O / tetrahydrofuran / 40 °C

4.1: CH₂Cl₂ / 20 °C

5.1: HCl / ethanol; ethyl acetate / 20 °C

With hydrogenchloride; sodium tetrahydroborate; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; 3.1: Staudinger reduction;

DOI:10.1016/j.bmcl.2006.05.066

upstream raw materials:

7-[(4-methyl-1-piperazinyl)methyl]-3-(2-thienyl)-1,4-dihydroindeno[1,2-c]pyrazole

Downstream raw materials:

{5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophen-2-yl}-methanol

C-{5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophen-2-yl}-methylamine

3-(5-azidomethyl-thiophen-2-yl)-1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazole

1-{5-[1-[bis-(4-methoxy-phenyl)-methyl]-7-(4-methyl-piperazin-1-ylmethyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-thiophen-2-ylmethyl}-3-m-tolyl-urea