3-((Z)-but-2-en-2-yl)-5-chloro-N'-hydroxy-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboximidamide

Base Information

Chemical Name:3-((Z)-but-2-en-2-yl)-5-chloro-N'-hydroxy-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboximidamide
CAS No.:1289206-00-3
Molecular Formula:C₁₆H₁₈ClN₃O₂
Molecular Weight:319.791
Hs Code.:

Synonyms:3-((Z)-but-2-en-2-yl)-5-chloro-N'-hydroxy-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboximidamide

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Chemical Property of 3-((Z)-but-2-en-2-yl)-5-chloro-N'-hydroxy-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboximidamide

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Technology Process of 3-((Z)-but-2-en-2-yl)-5-chloro-N'-hydroxy-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboximidamide

There total 9 articles about 3-((Z)-but-2-en-2-yl)-5-chloro-N'-hydroxy-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1289207-28-8
(Z)-3-(but-2-en-2-yl)-5-chloro-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile

: 1289206-00-3
3-((Z)-but-2-en-2-yl)-5-chloro-N'-hydroxy-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboximidamide

Guidance literature:: With hydroxylamine; In methanol; water; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 104-47-2
p-methoxybenzylnitrile

: 1289206-00-3
3-((Z)-but-2-en-2-yl)-5-chloro-N'-hydroxy-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboximidamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride; ethanol / diethyl ether; mineral oil / 20 °C

2.1: sodium acetate / water; methanol / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

4.2: 0.5 h / 20 °C

5.1: diiodomethane; isopentyl nitrite / acetonitrile / 1 h / 50 °C

6.1: N-chloro-succinimide / N,N-dimethyl-formamide / 16 h

7.1: boron tribromide / dichloromethane / 0 °C

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / 150 °C / Microwave irradiation

9.1: hydroxylamine / water; methanol / 0.5 h / 120 °C / Microwave irradiation

With N-chloro-succinimide; diiodomethane; ethanol; hydroxylamine; sodium acetate; boron tribromide; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1289207-24-4
5-chloro-3-iodo-4-(4-methoxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile

: 1289206-00-3
3-((Z)-but-2-en-2-yl)-5-chloro-N'-hydroxy-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 0 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / 150 °C / Microwave irradiation

3: hydroxylamine / water; methanol / 0.5 h / 120 °C / Microwave irradiation

With hydroxylamine; boron tribromide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; water;