6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dicyclohexylamine salt

Base Information

Chemical Name:6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dicyclohexylamine salt
CAS No.:1261283-94-6
Molecular Formula:C₁₂H₂₃N*C₂₂H₂₀ClF₂NO₄
Molecular Weight:617.176
Hs Code.:

6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dicyclohexylamine salt

Synonyms:6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dicyclohexylamine salt

Suppliers and Price of 6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dicyclohexylamine salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dicyclohexylamine salt

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dicyclohexylamine salt

There total 10 articles about 6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dicyclohexylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 697762-66-6
6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-[1-(S)-tert-butyldimethylsilyloxymethyl-2-methylprop-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

: 101-83-7
N-cyclohexyl-cyclohexanamine

: 1261283-94-6
6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dicyclohexylamine salt

Guidance literature:: 6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-[1-(S)-tert-butyldimethylsilyloxymethyl-2-methylprop-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester; With water; sodium hydroxide; at 55 ℃;

With hydrogenchloride; In water; isopropyl alcohol; at 10 - 15 ℃; pH=3 - 3.5;

N-cyclohexyl-cyclohexanamine; In ethyl acetate; isopropyl alcohol;

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 1261283-94-6
6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dicyclohexylamine salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 1.5 h / 20 °C / Cooling

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: 1H-imidazole / dichloromethane

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 6 h / 40 °C / Inert atmosphere

5.1: sodium hydroxide; water / 55 °C

5.2: 10 - 15 °C / pH 3 - 3.5

With 1H-imidazole; water; potassium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 161531-51-7
2,4-difluoro-5-iodobenzoic acid

: 1261283-94-6
6-(3-chloro-2-fluorobenzyl)-7-fluoro-1-((S)-1-hydroxymethyl-2-methylprop-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dicyclohexylamine salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 85 - 90 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / toluene / 4.5 h / 90 - 95 °C

3.1: toluene / 1.5 h / 20 °C / Cooling

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: 1H-imidazole / dichloromethane

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 6 h / 40 °C / Inert atmosphere

7.1: sodium hydroxide; water / 55 °C

7.2: 10 - 15 °C / pH 3 - 3.5

With 1H-imidazole; thionyl chloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;