4-chloro-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

Base Information

• Chemical Name: 4-chloro-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine
• CAS No.: 91713-43-8
• Molecular Formula: C₂₇H₂₄ClN₃O₅
• Molecular Weight: 505.958
• Mol file: 91713-43-8.mol

Synonyms:4-chloro-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

Chemical Property of 4-chloro-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine

There total 6 articles about 4-chloro-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

→ 4-chloro-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine (91713-43-8)

Guidance literature:

Reference yield: 79.0%

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) + 4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 4-chloro-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine (91713-43-8)

Guidance literature:

With potassium hydroxide; Tris(3,6-dioxaheptyl)amine; In acetonitrile; at 20 ℃; for 0.333333h;

DOI:10.1021/jo071236p

Reference yield: 32.0%

2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythropentofuranosyl chloride (3056-12-0,3601-89-6,4330-21-6,52304-86-6,141846-57-3) + 4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 4-chloro-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine (91713-43-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2022.114165

upstream raw materials:

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

D-2-deoxyribose

1-O-methyl-2-deoxy-D-ribofuranoside

Downstream raw materials:

4-chloro-7-<2-deoxy-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>-pyrimidine

4-Chloro-7-(2-deoxy-5-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

4-Chloro-7-(2-deoxy-3-O-(p-toluoyl)-β-D-erythro-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

2'-deoxy-7-deazaadenosine