(S)-1-carbamoyl-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate

Base Information

• Chemical Name: (S)-1-carbamoyl-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate
• CAS No.: 125150-55-2
• Molecular Formula: C₂₃H₃₁N₃O₃
• Molecular Weight: 397.517
• Mol file: 125150-55-2.mol

Synonyms:(S)-1-carbamoyl-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate

Chemical Property of (S)-1-carbamoyl-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-carbamoyl-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate

There total 5 articles about (S)-1-carbamoyl-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → (S)-1-carbamoyl-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate (125150-55-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) NaNO₂, 0.5 M H₂SO₄, 2.) NaOH / 1.) water, -2-0 deg C, 3 h, overnight, room temp., 2.) water, pH=4.5-5.0

2: 96 percent / dimethylformamide / 24 h / Ambient temperature

3: 88 percent / DCC, 4-(N-pyrrolidino)pyridine / CH₂Cl₂ / 6 h / Ambient temperature

4: 100 percent / hydrogen / 5percent Pd-on charcoal / ethyl acetate / 760 Torr

5: 1.) (COCl)2, DMF, 2.) aq. NH₃ / 1.) benzene, 3 h, room temp., 2.) diglyme, 30 min, room temp.

With ammonium hydroxide; sodium hydroxide; oxalyl dichloride; sulfuric acid; hydrogen; 4-pyrrolidin-1-ylpyridine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; sodium nitrite; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

(S)-2-hydroxy-3-methylbutyric acid benzyl ester (65138-05-8) → (S)-1-carbamoyl-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate (125150-55-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / DCC, 4-(N-pyrrolidino)pyridine / CH₂Cl₂ / 6 h / Ambient temperature

2: 100 percent / hydrogen / 5percent Pd-on charcoal / ethyl acetate / 760 Torr

3: 1.) (COCl)2, DMF, 2.) aq. NH₃ / 1.) benzene, 3 h, room temp., 2.) diglyme, 30 min, room temp.

With ammonium hydroxide; oxalyl dichloride; hydrogen; 4-pyrrolidin-1-ylpyridine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;

Reference yield:

(S)-(-)-sodium 2-hydroxy-3-methylbutanoate (54641-19-9) → (S)-1-carbamoyl-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate (125150-55-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / dimethylformamide / 24 h / Ambient temperature

2: 88 percent / DCC, 4-(N-pyrrolidino)pyridine / CH₂Cl₂ / 6 h / Ambient temperature

3: 100 percent / hydrogen / 5percent Pd-on charcoal / ethyl acetate / 760 Torr

4: 1.) (COCl)2, DMF, 2.) aq. NH₃ / 1.) benzene, 3 h, room temp., 2.) diglyme, 30 min, room temp.

With ammonium hydroxide; oxalyl dichloride; hydrogen; 4-pyrrolidin-1-ylpyridine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

(S)-1-carboxy-2-methylpropyl 4-(5-heptylpyrimidin-2-yl)benzoate

L-valine

(S)-2-hydroxy-3-methylbutyric acid benzyl ester

(S)-(-)-sodium 2-hydroxy-3-methylbutanoate