(3aR,6aR)-N-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3 ,4-b]pyrrole-5(1 H)-carboxamide

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Chemical Name:(3aR,6aR)-N-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3 ,4-b]pyrrole-5(1 H)-carboxamide
CAS No.:1353644-68-4
Molecular Formula:C₃₁H₃₁FN₈O₂
Molecular Weight:566.638
Hs Code.:

Synonyms:(3aR,6aR)-N-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3 ,4-b]pyrrole-5(1 H)-carboxamide

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Chemical Property of (3aR,6aR)-N-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3 ,4-b]pyrrole-5(1 H)-carboxamide

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Technology Process of (3aR,6aR)-N-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3 ,4-b]pyrrole-5(1 H)-carboxamide

There total 12 articles about (3aR,6aR)-N-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3 ,4-b]pyrrole-5(1 H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55496-69-0
4-chloro-7-methoxy-6-nitroquinazoline

: 1353644-68-4
(3aR,6aR)-N-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3 ,4-b]pyrrole-5(1 H)-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,4-dioxane / 3 h / Reflux

2: hydrogen / Raney's nickel / methanol / 4 h / 20 °C / Inert atmosphere

3: pyridine / N,N-dimethyl-formamide / 1 h / 20 °C

4: pyridine / N,N-dimethyl-formamide / 1 h / 80 °C

With pyridine; hydrogen; Raney's nickel; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1353644-77-5
(3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole

: 1353644-76-4
C₃₀H₂₃FN₆O₃

: 1353644-68-4
(3aR,6aR)-N-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3 ,4-b]pyrrole-5(1 H)-carboxamide

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield:

: 5401-94-5
5-nitroindazole

: 1353644-68-4
(3aR,6aR)-N-(4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3 ,4-b]pyrrole-5(1 H)-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

2: hydrogen / Raney's nickel / methanol / 20 °C / Inert atmosphere

3: 1,4-dioxane / 3 h / Reflux

4: hydrogen / Raney's nickel / methanol / 4 h / 20 °C / Inert atmosphere

5: pyridine / N,N-dimethyl-formamide / 1 h / 20 °C

6: pyridine / N,N-dimethyl-formamide / 1 h / 80 °C

With pyridine; hydrogen; potassium carbonate; Raney's nickel; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;