(S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate

Base Information

Chemical Name:(S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate
CAS No.:1351987-31-9
Molecular Formula:C₄₀H₅₅NO₁₀
Molecular Weight:709.877
Hs Code.:

Synonyms:(S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate

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Chemical Property of (S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate

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Technology Process of (S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate

There total 20 articles about (S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1351987-30-8
(5S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methyl-3-oxoheptanoate

: 108-24-7
acetic anhydride

: 1351987-31-9
(S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate

Guidance literature:: With triethylamine; dmap; for 3h; Inert atmosphere;

Reference yield:

: 172900-75-3
4-methoxy-3-(3-methoxypropoxy)benzaldehyde

: 1351987-31-9
(S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium diisopropyl amide / n-heptane; benzene; tetrahydrofuran / 1 h / -40 °C / Inert atmosphere

1.2: 2.25 h / -40 °C

2.1: camphor-10-sulfonic acid / toluene / Dean-Stark system; Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr

4.1: hydrogenchloride; 2-amino-2-hydroxymethyl-1,3-propanediol; water; HLAP / 48 h / 40 °C / Enzymatic reaction

4.2: 20 °C / pH 3.5

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere

5.2: 20 °C

6.1: potassium carbonate; tetrabutyl-ammonium chloride; sodium hydrogencarbonate / N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 3 h / 20 °C

7.1: pyridine; titanium tetrachloride / dichloromethane; tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

8.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 24 h / 760.05 Torr

9.1: triethylamine / dmap / 3 h / Inert atmosphere

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; HLAP; tetrabutyl-ammonium chloride; water; hydrogen; titanium tetrachloride; sodium hydrogencarbonate; potassium carbonate; triethylamine; 2-amino-2-hydroxymethyl-1,3-propanediol; lithium diisopropyl amide; dmap; N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; n-heptane; dichloromethane; water; toluene; benzene; 7.1: Knoevenagel Condensation;

Reference yield:

: 172900-71-9
(R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid

: 1351987-31-9
(S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere

1.2: 20 °C

2.1: potassium carbonate; tetrabutyl-ammonium chloride; sodium hydrogencarbonate / N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 3 h / 20 °C

3.1: pyridine; titanium tetrachloride / dichloromethane; tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 24 h / 760.05 Torr

5.1: triethylamine / dmap / 3 h / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; tetrabutyl-ammonium chloride; hydrogen; titanium tetrachloride; sodium hydrogencarbonate; potassium carbonate; triethylamine; dmap; N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; water; 3.1: Knoevenagel Condensation;