Technology Process of (3R,3aR,7aS)-7a-(phenylsulfonyl)-3-propyl-3a,4,7,7a-tetrahydroisobenzofuran-1(3H)-one
There total 12 articles about (3R,3aR,7aS)-7a-(phenylsulfonyl)-3-propyl-3a,4,7,7a-tetrahydroisobenzofuran-1(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
dichloromethane;
at 40 ℃;
for 3h;
DOI:10.1021/ol0478739
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 94 percent / Ti(OPr-i)4 / CH2Cl2 / 2 h / 20 °C
2.1: NaIO4; tetrabutylammonium periodate / methanol; H2O / 1 h / 20 °C
2.2: 73 percent / sodium hydride / benzene / 0.5 h
3.1: 95 percent / sodium hydride / dimethylformamide / 4 h
4.1: 92 percent / NaOH / tetrahydrofuran; H2O / 1 h
5.1: 88 percent / BH3*SMe2 / tetrahydrofuran / -10 - 20 °C
6.1: 93 percent / KHSO5 / methanol; H2O / 5 h
7.1: dimethylformamide / 0.25 h / 0 °C
7.2: 75 percent / dimethylformamide / 4 h / 20 °C
8.1: methyl suldoxide; triethylamine; SO3*pyridine / CH2Cl2 / 4 h / 20 °C
9.1: 316 mg / potassium hexamethyldisilazane / toluene; tetrahydrofuran / 1 h / -40 °C
10.1: 85 percent / second generation Grubbs catalyst / CH2Cl2 / 3 h / 40 °C
With
titanium(IV) isopropylate; sodium hydroxide; sodium periodate; potassium peroxomonosulfate; potassium hexamethyldisilazane; pyridine-SO3 complex; dimethylsulfide borane complex; sodium hydride; tetrabutylammonium periodite; dimethyl sulfoxide; triethylamine;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.jorganchem.2006.08.021
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dimethylformamide / 0.25 h / 0 °C
1.2: 75 percent / dimethylformamide / 4 h / 20 °C
2.1: methyl suldoxide; triethylamine; SO3*pyridine / CH2Cl2 / 4 h / 20 °C
3.1: 316 mg / potassium hexamethyldisilazane / toluene; tetrahydrofuran / 1 h / -40 °C
4.1: 85 percent / second generation Grubbs catalyst / CH2Cl2 / 3 h / 40 °C
With
potassium hexamethyldisilazane; pyridine-SO3 complex; dimethyl sulfoxide; triethylamine;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.jorganchem.2006.08.021
