3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Base Information

Chemical Name:3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester
CAS No.:366793-00-2
Molecular Formula:C₄₇H₅₃N₇O₁₁
Molecular Weight:891.978
Hs Code.:

3-{benzyloxy-[({[2-(<i>N</i>'-<i>tert</i>-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9<i>H</i>-fluoren-9-ylmethyl) ester

Synonyms:3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

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Chemical Property of 3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

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Technology Process of 3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

There total 8 articles about 3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23776-83-2
N'-(2-aminoacetyl)hydrazinecarboxylic acid tert-butyl ester

: 366793-00-2
3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: DCC; DMAP / CH₂Cl₂ / 24 h / 20 °C

2: 100 percent / H₂ / 20percent Pd(OH)2/C / methanol / 8 h / 20 °C

3: BOP-Cl; Et₃N / CH₂Cl₂ / -20 - 0 °C

With dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; dicyclohexyl-carbodiimide; 20percent Pd(OH)2/C; In methanol; dichloromethane;
DOI:10.1021/ol016440s

Reference yield:

: 366792-99-6
N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester

: 366793-00-2
3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 20percent Pd(OH)2/C / methanol / 8 h / 20 °C

2: BOP-Cl; Et₃N / CH₂Cl₂ / -20 - 0 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; 20percent Pd(OH)2/C; In methanol; dichloromethane;
DOI:10.1021/ol016440s

Reference yield:

: 366792-96-3
N'-[(2-methylamino-acetylamino)-acetyl]-hydrazinecarboxylic acid tert-butyl ester

: 366792-95-2
3-(benzyloxy-carboxymethyl-carbamoyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

: 366793-00-2
3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at -20 - 0 ℃;
DOI:10.1021/ol016440s