(S)-2-[2-(1-tert-Butoxycarbonylamino-cyclobutyl)-acetylamino]-3-methyl-butyric acid benzyl ester

Base Information

Chemical Name:(S)-2-[2-(1-tert-Butoxycarbonylamino-cyclobutyl)-acetylamino]-3-methyl-butyric acid benzyl ester
CAS No.:204132-48-9
Molecular Formula:C₂₃H₃₄N₂O₅
Molecular Weight:418.533
Hs Code.:

Synonyms:(S)-2-[2-(1-tert-Butoxycarbonylamino-cyclobutyl)-acetylamino]-3-methyl-butyric acid benzyl ester

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Chemical Property of (S)-2-[2-(1-tert-Butoxycarbonylamino-cyclobutyl)-acetylamino]-3-methyl-butyric acid benzyl ester

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Technology Process of (S)-2-[2-(1-tert-Butoxycarbonylamino-cyclobutyl)-acetylamino]-3-methyl-butyric acid benzyl ester

There total 3 articles about (S)-2-[2-(1-tert-Butoxycarbonylamino-cyclobutyl)-acetylamino]-3-methyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 21760-98-5
L-valine benzyl ester

: 204132-37-6
2-oxo-1-azaspiro[3.3]heptane-1-carboxylic acid tert-butyl ester

: 204132-48-9
(S)-2-[2-(1-tert-Butoxycarbonylamino-cyclobutyl)-acetylamino]-3-methyl-butyric acid benzyl ester

Guidance literature:: With potassium cyanide; In N,N-dimethyl-formamide; at 40 ℃; for 16h;
DOI:10.1021/jo9712862

Reference yield:

: 1120-56-5
methylidenecyclobutane

: 204132-48-9
(S)-2-[2-(1-tert-Butoxycarbonylamino-cyclobutyl)-acetylamino]-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 0 °C

2: 0.80 g / Na₂SO₃, KOH / diethyl ether; H₂O

3: 80 percent / 4-(dimethylamino)pyridine / acetonitrile / Ambient temperature

4: 93 percent / potassium cyanide / dimethylformamide / 16 h / 40 °C

With dmap; potassium cyanide; potassium hydroxide; sodium sulfite; In diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo9712862

Reference yield:

: 2-Oxo-1-aza-spiro[3.3]heptane-1-sulfonyl chloride

: 204132-48-9
(S)-2-[2-(1-tert-Butoxycarbonylamino-cyclobutyl)-acetylamino]-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 0.80 g / Na₂SO₃, KOH / diethyl ether; H₂O

2: 80 percent / 4-(dimethylamino)pyridine / acetonitrile / Ambient temperature

3: 93 percent / potassium cyanide / dimethylformamide / 16 h / 40 °C

With dmap; potassium cyanide; potassium hydroxide; sodium sulfite; In diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo9712862