1,1-dimethylethyl (4S)-2,2,4-trimethyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl (4S)-2,2,4-trimethyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate
CAS No.:1005407-69-1
Molecular Formula:C₂₈H₄₂F₃N₃O₆
Molecular Weight:573.653
Hs Code.:

1,1-dimethylethyl (4S)-2,2,4-trimethyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

Synonyms:1,1-dimethylethyl (4S)-2,2,4-trimethyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

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Chemical Property of 1,1-dimethylethyl (4S)-2,2,4-trimethyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

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Technology Process of 1,1-dimethylethyl (4S)-2,2,4-trimethyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

There total 5 articles about 1,1-dimethylethyl (4S)-2,2,4-trimethyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1005407-66-8
4-(n-octyloxy)-3-(trifluoromethyl)benzohydrazide

: 1005407-69-1
1,1-dimethylethyl (4S)-2,2,4-trimethyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

Guidance literature:: (4S)-3-(tert-butoxycarbonyl)-2,2,4-trimethyl-1,3-oxazolidine-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 18 - 23 ℃; for 0.166667 - 1.25h;

4-(n-octyloxy)-3-(trifluoromethyl)benzohydrazide; In dichloromethane; N,N-dimethyl-formamide; at 18 - 23 ℃; for 1 - 1.25h; Product distribution / selectivity;

Reference yield: 82.0%

: 876915-46-7
(4S)-3-(tert-butoxycarbonyl)-2,2,4-trimethyl-1,3-oxazolidine-4-carboxylic acid

: 1005407-66-8
4-(n-octyloxy)-3-(trifluoromethyl)benzohydrazide

: 1005407-69-1
1,1-dimethylethyl (4S)-2,2,4-trimethyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

Guidance literature:: (4S)-3-(tert-butoxycarbonyl)-2,2,4-trimethyl-1,3-oxazolidine-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; for 0.166667h;

4-(n-octyloxy)-3-(trifluoromethyl)benzohydrazide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/ml400194r

Reference yield:

: 1005407-63-5
4-(n-octyloxy)-3-(trifluoromethyl)benzoic acid

: 1005407-69-1
1,1-dimethylethyl (4S)-2,2,4-trimethyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / 2-methyltetrahydrofuran / 25 °C / Large scale reaction

1.2: 25 °C / Large scale reaction

2.1: 1,1'-carbonyldiimidazole / 2-methyltetrahydrofuran; isopropyl alcohol / 1.5 h / 40 °C

2.2: 3 h / 40 °C

With 1,1'-carbonyldiimidazole; In 2-methyltetrahydrofuran; isopropyl alcohol;
DOI:10.1021/op2000095