N2-(3-((5-(3-formylphenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-arginine

Base Information

Chemical Name:N2-(3-((5-(3-formylphenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-arginine
CAS No.:1268618-50-3
Molecular Formula:C₃₉H₄₃N₅O₁₀S₃
Molecular Weight:837.996
Hs Code.:

N2-(3-((5-(3-formylphenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-arginine

Synonyms:N2-(3-((5-(3-formylphenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-arginine

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Chemical Property of N2-(3-((5-(3-formylphenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-arginine

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Technology Process of N2-(3-((5-(3-formylphenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-arginine

There total 6 articles about N2-(3-((5-(3-formylphenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268618-45-6
(S)-2-{[3-(5-bromo-2,3-dihydrobenzofuran-7-sulfonylamino)thiophene-2-carbonyl]amino}-5-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonylguanidino)pentanoic acid

: 87199-16-4
3-Formylphenylboronic acid

: 1268618-50-3
N2-(3-((5-(3-formylphenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-arginine

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 0.166667h; Microwave irradiation, 100 watts;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1268618-50-3
N2-(3-((5-(3-formylphenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-arginine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 20 h / 20 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 h / 45 °C

2.2: pH 1

3.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 18 h / 20 °C

4.1: water; lithium hydroxide / 3 h / 20 °C

4.2: pH 1

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.17 h / 90 °C / Microwave irradiation, 100 watts

With pyridine; potassium phosphate; water; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; 5.1: Suzuki Coupling;

Reference yield:

: 690632-00-9
5-bromo-2,3-dihydrobenzofuran-7-sulfonyl chloride

: 1268618-50-3
N2-(3-((5-(3-formylphenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-Nω-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)-L-arginine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 20 h / 20 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 h / 45 °C

2.2: pH 1

3.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 18 h / 20 °C

4.1: water; lithium hydroxide / 3 h / 20 °C

4.2: pH 1

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.17 h / 90 °C / Microwave irradiation, 100 watts

With pyridine; potassium phosphate; water; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; 5.1: Suzuki Coupling;