1-(4-benzoyl-1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)-2,2-difluoroethanone

Base Information

Chemical Name:1-(4-benzoyl-1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)-2,2-difluoroethanone
CAS No.:1594782-21-4
Molecular Formula:C₁₉H₁₂F₃NO₃
Molecular Weight:359.304
Hs Code.:

Synonyms:1-(4-benzoyl-1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)-2,2-difluoroethanone

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Chemical Property of 1-(4-benzoyl-1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)-2,2-difluoroethanone

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Technology Process of 1-(4-benzoyl-1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)-2,2-difluoroethanone

There total 4 articles about 1-(4-benzoyl-1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)-2,2-difluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 401-67-2
2,2-difluoroacetic anhydride

: 1594781-85-7
[1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone

: 1594782-21-4
1-(4-benzoyl-1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)-2,2-difluoroethanone

Guidance literature:: In 1,2-dichloro-ethane; at 180 ℃; for 5h; Microwave irradiation;
DOI:10.1016/j.bmc.2014.02.016

Reference yield:

: 1339084-93-3
2-fluoro-4-(1H-pyrrol-1-yl)phenol

: 1594782-21-4
1-(4-benzoyl-1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)-2,2-difluoroethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 24 h / 20 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: 1,2-dichloro-ethane / 5 h / 180 °C / Microwave irradiation

With aluminum (III) chloride; In 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.02.016

Reference yield:

: C₂₄H₁₆FNO₃

: 1594782-21-4
1-(4-benzoyl-1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)-2,2-difluoroethanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / 1,4-dioxane / 20 °C / Inert atmosphere

2: 1,2-dichloro-ethane / 5 h / 180 °C / Microwave irradiation

With water; sodium hydroxide; In 1,4-dioxane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.02.016