2-(4-(4-cyano-2-(methylsulfonyl)phenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetic acid

Base Information

Chemical Name:2-(4-(4-cyano-2-(methylsulfonyl)phenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetic acid
CAS No.:1625672-63-0
Molecular Formula:C₂₅H₂₀F₃N₃O₆S
Molecular Weight:547.512
Hs Code.:

Synonyms:2-(4-(4-cyano-2-(methylsulfonyl)phenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetic acid

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Chemical Property of 2-(4-(4-cyano-2-(methylsulfonyl)phenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetic acid

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Technology Process of 2-(4-(4-cyano-2-(methylsulfonyl)phenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetic acid

There total 5 articles about 2-(4-(4-cyano-2-(methylsulfonyl)phenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1625669-55-7
4-(1-(3-(trifluoromethyl)phenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-3-(methylsulfonyl)benzonitrile

: 1625672-63-0
2-(4-(4-cyano-2-(methylsulfonyl)phenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetic acid

Guidance literature:: bromoacetic acid tert-butyl ester; 4-(1-(3-(trifluoromethyl)phenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-3-(methylsulfonyl)benzonitrile; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

With trifluoroacetic acid; In acetonitrile; at 20 ℃; for 6h;

Reference yield:

: 849035-77-4
4-bromo-2-(methylsulfonyl)benzaldehyde

: 1625672-63-0
2-(4-(4-cyano-2-(methylsulfonyl)phenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethyl phosphate; phosphorus pentoxide / tert-butyl methyl ether / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

3.2: 6 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethyl phosphate; phosphorus pentoxide; caesium carbonate; In tert-butyl methyl ether; N,N-dimethyl-formamide;

Reference yield:

: 13114-87-9
N-(3-trifluoromethylphenyl)urea

: 1625672-63-0
2-(4-(4-cyano-2-(methylsulfonyl)phenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethyl phosphate; phosphorus pentoxide / tert-butyl methyl ether / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

3.2: 6 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethyl phosphate; phosphorus pentoxide; caesium carbonate; In tert-butyl methyl ether; N,N-dimethyl-formamide;