3-(4-methylbenzenesulfonyl)-2-(methylsulfanyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

Base Information

Chemical Name:3-(4-methylbenzenesulfonyl)-2-(methylsulfanyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
CAS No.:1452776-85-0
Molecular Formula:C₁₈H₁₈N₂O₃S₃
Molecular Weight:406.551
Hs Code.:

Synonyms:3-(4-methylbenzenesulfonyl)-2-(methylsulfanyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

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Chemical Property of 3-(4-methylbenzenesulfonyl)-2-(methylsulfanyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

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Technology Process of 3-(4-methylbenzenesulfonyl)-2-(methylsulfanyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

There total 5 articles about 3-(4-methylbenzenesulfonyl)-2-(methylsulfanyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1452849-76-1
(Z)-2-((4-methylbenzenesulfonamido)(methylsulfanyl)-methyleneamino)-4,5,6,7-tetra-hydrobenzo[b]thiophene-3-carboxylic acid

: 1452776-85-0
3-(4-methylbenzenesulfonyl)-2-(methylsulfanyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.75h;
DOI:10.1021/jo4010876

Reference yield:

: 92932-02-0
2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid tert-butyl ester

: 1452776-85-0
3-(4-methylbenzenesulfonyl)-2-(methylsulfanyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: calcium carbonate / water; dichloromethane / 0.67 h / 0 °C

2: potassium carbonate / acetone / 20 h / Reflux

3: water; sodium hydroxide / ethanol / 2 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.75 h / 20 °C

With oxalyl dichloride; water; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; calcium carbonate; sodium hydroxide; In ethanol; dichloromethane; water; acetone;
DOI:10.1021/jo4010876

Reference yield:

: 1452776-82-7
tert-butyl 2-(3-(4-methylbenzenesulfonyl)thioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 1452776-85-0
3-(4-methylbenzenesulfonyl)-2-(methylsulfanyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / ethanol / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.75 h / 20 °C

With oxalyl dichloride; water; N,N-dimethyl-formamide; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1021/jo4010876