N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysine tert-butyl ester

Base Information

• Chemical Name: N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysine tert-butyl ester
• CAS No.: 120008-84-6
• Molecular Formula: C₄₀H₅₉N₃O₈
• Molecular Weight: 709.924
• Mol file: 120008-84-6.mol

Synonyms:N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysine tert-butyl ester

Chemical Property of N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysine tert-butyl ester

There total 1 articles about N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

Nε-benzyloxycarbonyl-L-lysine tert-butyl ester (63628-63-7) + ethyl 7-(1-benzyloxycarbonyl-4-piperidyl)-2-chloroheptanoate (120008-91-5) → Nα-<1(R)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-Nε-benzyloxycarbonyl-L-lysine tert-butyl ester (129388-76-7) + Nα-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-Nε-benzyloxycarbonyl-L-lysine tert-butyl ester (120008-84-6)

Guidance literature:

With triethylamine; potassium iodide; In acetonitrile; for 72h; Heating;

Reference yield: 85.0%

Nα-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-Nε-benzyloxycarbonyl-L-lysine tert-butyl ester (120008-84-6) → Nα-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-Nε-benzyloxycarbonyl-L-lysine (129297-31-0)

Guidance literature:

With formic acid; at 40 ℃; for 30h;

Reference yield:

Nα-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-Nε-benzyloxycarbonyl-L-lysine tert-butyl ester (120008-84-6) → Nα-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-Nε-benzyloxycarbonyl-L-lysyl-L-proline tert-butyl ester (120008-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / 99percent formic acid / 30 h / 40 °C

2: 96 percent / diethyl phosphorocyanidate, Et₃N / dimethylformamide / 3 h

With formic acid; diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide;

upstream raw materials:

Nε-benzyloxycarbonyl-L-lysine tert-butyl ester

ethyl 7-(1-benzyloxycarbonyl-4-piperidyl)-2-chloroheptanoate

Downstream raw materials:

N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysine

N^α-<1(S)-ethoxycarbonyl-6-(1-benzyloxycarbonyl-4-piperidyl)hexyl>-N^ε-benzyloxycarbonyl-L-lysyl-L-proline tert-butyl ester