1-(3-((4-trifluoromethoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea

Base Information

Chemical Name:1-(3-((4-trifluoromethoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea
CAS No.:1373331-91-9
Molecular Formula:C₁₉H₁₈F₃N₃O₂
Molecular Weight:377.366
Hs Code.:

Synonyms:1-(3-((4-trifluoromethoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea

Suppliers and Price of 1-(3-((4-trifluoromethoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-(3-((4-trifluoromethoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(3-((4-trifluoromethoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea

There total 4 articles about 1-(3-((4-trifluoromethoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.34%

: 1373331-84-0
1-(3-(chloromethyl)phenyl)-3-(prop-2-yn-1-yl)urea

: 93919-56-3
4-(trifluoromethoxy)benzyl amine

: 1373331-91-9
1-(3-((4-trifluoromethoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1016/j.bmcl.2012.02.029

Reference yield:

: 117098-59-6
DPPA

: 1373331-91-9
1-(3-((4-trifluoromethoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-dioxane / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 60 °C

With potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.02.029

Reference yield:

: 31719-77-4
3-chloromethylbenzoic acid

: 1373331-91-9
1-(3-((4-trifluoromethoxybenzylamino)methyl)phenyl)-3-(prop-2-yn-1-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: diphenyl phosphoryl azide; triethylamine / 1,4-dioxane / 0.5 h / 20 °C

2: 1,4-dioxane / 2 h / 100 °C

3: 1,4-dioxane / 1 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 60 °C

With diphenyl phosphoryl azide; potassium carbonate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; 2: Curtius rearrangement;
DOI:10.1016/j.bmcl.2012.02.029