(R)-1-[1-(2-cyano-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl] piperidin-3-yl tert-butyl carbamate

Base Information

Chemical Name:(R)-1-[1-(2-cyano-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl] piperidin-3-yl tert-butyl carbamate
CAS No.:1314945-35-1
Molecular Formula:C₂₅H₃₀N₆O₃
Molecular Weight:462.552
Hs Code.:

Synonyms:(R)-1-[1-(2-cyano-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl] piperidin-3-yl tert-butyl carbamate

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Chemical Property of (R)-1-[1-(2-cyano-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl] piperidin-3-yl tert-butyl carbamate

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Technology Process of (R)-1-[1-(2-cyano-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl] piperidin-3-yl tert-butyl carbamate

There total 7 articles about (R)-1-[1-(2-cyano-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl] piperidin-3-yl tert-butyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1314945-32-8
(R)-1-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl)piperidin-3-yl tert-butyl carbamate

: 22115-41-9
2-(bromomethyl)benzonitrile

: 1314945-35-1
(R)-1-[1-(2-cyano-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl] piperidin-3-yl tert-butyl carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at -10 - 20 ℃; for 1h;

Reference yield:

: 1314945-26-0
tert-butyl (R)-(1-(2-chloro-3-nitropyridine-4-yl)piperidine-3-yl)carbamate

: 1314945-35-1
(R)-1-[1-(2-cyano-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl] piperidin-3-yl tert-butyl carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: butan-1-ol; ethanol / 24 h / 110 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

3: triethylamine / tetrahydrofuran / 0.5 h / -10 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / -10 - 20 °C

With hydrogen; potassium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1314945-28-2
(R)-1-[2-(methylamino)-3-nitropyridin-4-yl]piperidin-3-yl tert-butyl carbamate

: 1314945-35-1
(R)-1-[1-(2-cyano-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl] piperidin-3-yl tert-butyl carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

2: triethylamine / tetrahydrofuran / 0.5 h / -10 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / -10 - 20 °C

With hydrogen; potassium carbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;